True Blue may refer to:

• True Blue (Tina Brooks album), 1960
• True Blue (Hank Crawford album), 1964
• True Blue (Al Cohn and Dexter Gordon album), 1976
• True Blue (Madonna album), 1986
  • "True Blue" (Madonna song), the title track and single off the album
• "True Blue", a 1972 song from the Rod Stewart album Never a Dull Moment
• True Blue – The Very Best of John Williamson, 1995 album
  • "True Blue" (John Williamson song), a song from the album
• "True Blue" (Luna Sea song), a 1994 single by Luna Sea
• "True Blue" (Tullycraft song), 7" debut single by Tullycraft
• "True Blue", a song by Bright Eyes from the single "Lua"
• "True Blue", a song by Dirty Beaches from the album Badlands
• "True Blue", a song by Zone used as the opening theme of Astro Boy
• "True Blue", a song by boygenius from the album The Record.
• True Blue: The Best of Sonic the Hedgehog, a compilation album of songs from the Sonic the Hedgehog franchise
• True Blue, a companion CD issued with Frank Black & the Catholics Box Set, released May 2015
• True Blue, a 2005 CD by Bob Mosley, on Taxim Records

• True Blue (1918 film), an American western film directed by Frank Lloyd
• True Blue (1996 film), a film based on the 1989 Dan Topolski and Patrick Robinson book
• True Blue (2001 film), a crime thriller starring Tom Berenger and Lori Heuring

• True Blue (novel), a 2009 novel by David Baldacci
• True Blue (TV series), a television drama airing 1989–1990
• True Blue: The Oxford Boat Race Mutiny, a 1989 book by Dan Topolski and Patrick Robinson

• True Blue (color), a school color of UCLA
• Coventry blue, a blue-dyed cloth renowned for its permanence
• True blue, the French term pure laine, a politically and culturally charged phrase
• True Blue, a racehorse who finished fourth in the 1839 Grand National
• The True Blue Campus of St. George's University, Grenada
• True Blue, codename for the planning of the funeral of Margaret Thatcher

• Tru Blu