Thomas Pickering may refer to:

• Thomas Pickering (martyr) (c. 1621–1679), English religious leader
• Thomas R. Pickering (born 1931), American diplomat—UN Ambassador
• Thomas G. Pickering (1940–2009), professor of medicine at Columbia University Medical Center
• Tom Pickering (footballer) (1906-unknown), English footballer
• Tom Pickering, fictional character in Hated in the Nation

• Timothy Pickering (1745–1829), American diplomat—Secretary of State