Thomas Patterson may refer to:

• Thomas Patterson (Pennsylvania politician) (1764–1841), United States Congressman from Pennsylvania
• Thomas Patterson (Arizona politician), member of the Arizona State Senate
• Thomas H. Patterson (1820–1889), U.S. naval officer during the American Civil War
• Thomas M. Patterson (1839–1916), United States Representative and Senator from Colorado
• Thomas C. Patterson, American politician
• Tom Patterson (theatre producer) (1920–2005), Canadian journalist and festival manager
• Tom Patterson (baseball) (1845–1900), Major League Baseball outfielder
• Thomas Patterson (cricketer) (1839–?), Australian cricketer
• Thomas Stewart Patterson (1872–1949), Scottish organic chemist
• Thomas E. Patterson, American political scientist
• Tom Patterson (basketball) (1948–1982), basketball forward
• Tom Patterson (entrepreneur) (born 1979), American entrepreneur
• Tom Patterson (Florida politician) (born 1943), American politician in the state of Florida
• Tom Patterson (Arrowverse), a character from The Flash

• Thomas Paterson (disambiguation)