The zodiac is a coordinate system of twelve "signs", based on twelve constellations used in astronomy and astrology.

Zodiac may also refer to:

• Zodiac (ride), a ride at Thorpe Park, United Kingdom
• Zodiac, a double Ferris wheel

• Zodiac-films, a 1970s series of Danish erotic films
• The Zodiac Killer (film), 1971 film about the Zodiac Killer, released while the serial murderer was still actively sending letters
• Zodiac Rapist (1971), a pornographic horror film loosely based on the crimes of the Zodiac Killer
• The Zodiac (film), a 2005 film by Alexander Buckley about the Zodiac Killer
• Curse of the Zodiac (2007) horror film, a loose retelling of the original murders
• Zodiac (film), a 2007 film by David Fincher based on a book about the Zodiac Killer
• Zodiac: Signs of the Apocalypse, a 2014 Canadian science fiction disaster television film
• Awakening the Zodiac (2017), a mystery drama about the Zodiac Killer

• Zodiac (true crime book), a 1986 book by Robert Graysmith about the Zodiac Killer
• Zodiac (novel), a 1988 novel by Neal Stephenson about environmentalism
• Short Trips: Zodiac (2002), an anthology about Doctor Who
• Zodiac (comics), several groups of supervillains in the Marvel Universe
• Zodiacs (Hunter × Hunter), a group of characters in the manga series Hunter × Hunter

• Zodiac (German band), a German hard/blues rock band
• Zodiac (Latvian band), a Soviet Union, then Latvian musical group
• Maurice Williams and the Zodiacs, a band

• Zodiac (Cecil Payne album)
• Zodiac (Electric Six album) (2010)
• Zodiac (soundtrack), the soundtrack from the 2007 film
• The Zodiac: Cosmic Sounds, a 1967 psychedelic concept album

• "Zodiac", a song by Yaron Chadad representing Israel in the Eurovision Song Contest 1992
• "Zodiac", a 1999 song by Richie Havens from Time
• "Zodiac", a song by Ryan Leslie
• "The Zodiac", a song by Kamelot
• "Zodiacs", a song by Roberta Kelly
• "Zodiac", a song by Melvins
• "Zodiac", a song by God Is an Astronaut from their self-titled album
• "Zodiac", a song by Macabre from their album Sinister Slaughter

• The Zodiac, a former name of the O2 Academy Oxford, a nightclub and music venue in Oxford, England
• Zodiac Records (New Zealand), a record label
• Zodiac Records, a list of record labels
• Zodiak Free Arts Lab, an experimental music venue in West Berlin

• Orange County Zodiac, a former American soccer team
• Zodiac Aerospace, a corporation specializing in the production of aerosafety systems
• Zodiac Entertainment, an American television production/distribution company
• Zodiac Marine & Pool, a corporation specializing in the production of Zodiac rigid inflatable boats
• Zodiac Milpro, a company producing rigid inflatable boats for military and professional clients
• Zodiac Watches, a brand of watches

• Zodiac, a climbing route on the El Capitan rock formation in Yosemite Valley
• Zodiac, Missouri
• Zodiac Springs, a spring in Missouri
• Zodiac, Texas

• AMD Zodiac, a light sport aircraft
• Zephyr Zodiac, the luxury variant of the Ford Zephyr line of cars
• Zodiac inflatable boat
• Zodiac (schooner), a historic schooner homeported in Seattle, Washington, USA

• The Zodiac Killer, an unidentified serial killer in the San Francisco area, California
• Heriberto Seda, a serial killer known as the "New York Zodiac Killer"
• Brutus Beefcake or "the Zodiac", American retired professional wrestler
• Tapwave Zodiac, a palmtop computer
• Zodiac (cipher), a Korean encryption algorithm
• Zodiac: Orcanon Odyssey, a video game

• All pages with titles beginning with Zodiac
• All pages with titles containing Zodiac
• Tierkreis (Stockhausen) ("Zodiac" in German), a composition for 12 music boxes by Karlheinz Stockhausen
• Zodac, a character in the He-man and Masters of the Universe mythology