Odd Couple may refer to:

• The Odd Couple (play), a 1965 stage play by Neil Simon
  • The Odd Couple (film), a 1968 film based on the play
    • The Odd Couple (1970 TV series), a 1970–1975 television show based on the film
      • The Oddball Couple, a 1975–1977 animated TV series
      • The New Odd Couple, a 1982–1983 sitcom remake
      • The Odd Couple (2015 TV series), a 2015 remake
    • The Odd Couple II, 1998 sequel to the 1968 film
  • The Female Odd Couple, a version adapted by Simon in 1985 with the gender roles reversed

• Odd Couple (1979 film), a Hong Kong martial arts comedy film
• Odd Couple (2022 film), an Indian Hindi-language film
• The Odd Couple (album), a 2008 album by Gnarls Barkley
• "Odd Couple", a song by Gen Hoshino
• "Odd Couples", episode of The Suite Life of Zack & Cody
• "Odd Couples", an episode of the Indian adaptation The Suite Life of Karan & Kabir
• "Odd Couple", episode of The Fairly OddParents

• Couple (disambiguation)
• "Really Odd Couple", episode of The Grim Adventures of Billy & Mandy
• Buddy film, a film genre featuring a mismatched pair of lead characters, sometimes described as an "odd couple" pairing