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Nominator: RowanJ LP (talk · contribs) 17:32, 20 May 2024 (UTC)[reply]

Reviewer: Czarking0 (talk · contribs) 17:40, 7 January 2025 (UTC)[reply]

I'll take this one. Czarking0 (talk) 17:40, 7 January 2025 (UTC)[reply]

FYI this is really good work. I hope you take my comments as encouragement. I do not read a lot of Biology on WP and I really enjoyed this article. I sent it to a couple bio engineers I know. Czarking0 (talk) 18:34, 7 January 2025 (UTC)[reply]

Please reply to my comments inline with  Done or  Not done and additional detail based on what you think. I will then strike our discussion as we close out points.

• Furthermore, certain yeast species, like Schizosaccharomyces pombe and Cryptococcus neoformans, have unique mating behaviours and regulatory mechanisms, demonstrating the diversity and adaptability of yeast reproductive strategies. This sentence is a bit awkward and detailed for the lead. I suggest: "Certain yeast species have unique mating behaviors, demonstrating the diversity and adaptability of yeast reproductive strategies." Also is behaviours the British spelling? My spellcheck just marks it as wrong but I am American.Czarking0 (talk) 17:58, 7 January 2025 (UTC)[reply]
• I suggest restructuring the MAT locus section so that you start with what MAT is. Something like "MAT is an allele, located on chromosome III, which controls whether a cell will be \alpha or a. Somewhat outside the scope of GAR but I don't know that mating-type locus should be bluetext here. First, there is not really a difference between MAT and mating-type locus so I think just explaining MAT as an allele that controls the mating type is more useful than introducing a new vocabulary word. Second, the mating-type locus page is stub. It seems to indicate this concept in only relevant to yeast mating. In that case, I suggest that this section explains what the reader needs to know and then that stub is delete or merged.Czarking0 (talk) 17:58, 7 January 2025 (UTC)[reply]
• Haploid cells cannot undergo meiosis I might be forgetting some biology here, but this is just a general statement that really is not about yeast in particular right? If so, I think this should be removed as this article is fairly technical and the prerequisite knowledge is already past this point. Czarking0 (talk) 17:58, 7 January 2025 (UTC)[reply]
• Diploid cells do not produce or respond to either mating pheromone and do not mate, but they can undergo meiosis to produce four haploid cells. I think coverage on how this behavior is suppressed could be notable. In addition to the transcriptional patterns of a and α cells, haploid cells of both mating types share a haploid transcriptional pattern which activates haploid-specific genes (such as HO) and represses diploid-specific genes (such as IME1).[15] Conversely, diploid cells activate diploid-specific genes and repress haploid-specific genes.[16] The way I read this section I am led to believe that the behavior is activated/suppressed entirely through transcriptional processes. While I would expect that transcriptional processes play a part, is there really no epigenetic or ribosomal processes that factor in? Czarking0 (talk) 17:58, 7 January 2025 (UTC)[reply]
• Haploid cells only contain one copy of each of the 16 chromosomes and therefore only possess one MAT allele (either MATa or MATα), which determines their mating type. If you have to explain that haploid cells only have one of each chromosome then there is no way that the reader understood this article. Also, this info seems to be a restatement of the MAT section. Czarking0 (talk) 17:58, 7 January 2025 (UTC)[reply]
• Diploid cells result from the mating of an a cell and an α cell, and they possess 32 chromosomes (in 16 pairs), including one chromosome bearing the MATa allele and another chromosome bearing the MATα allele. I think you will want to rework the rest of this paragraph when you get to the other points. Czarking0 (talk) 17:58, 7 January 2025 (UTC)[reply]
• Kss1, a homologue of Fus3, does not affect shmooing, and does not contribute to the switch-like mating decision. This is entirely without context so it is hard for the reader to understand why this is notable. Czarking0 (talk) 18:17, 7 January 2025 (UTC)[reply]
• In yeast, mating as well as the production of shmoos occur via an all-or-none, switch-like mechanism Restructure this section so it begins here. The current beginning of this section can go after Thus, the above description of an a-type yeast stimulated with α-factor resembles the mechanism of an α-type yeast stimulated with a-factor then re-read the thing and ask yourself "what are the most notable points the reader needs to know" and "are those points clearly communicated". This probably warrants some bluetext on phosphorylation Czarking0 (talk) 18:17, 7 January 2025 (UTC)[reply]
• ultra-sensitivity to mating Do they really have ultra-sensitivity? What is the encyclopedic difference between sensitivity and ultra-sentitivity? Do you have a source for that?Czarking0 (talk) 18:18, 7 January 2025 (UTC)[reply]
• Wild type haploid yeast are capable of switching mating type between a and α. It is odd that this section begins with an explanation of wild type rather than what mating type switching is. Czarking0 (talk) 18:30, 7 January 2025 (UTC)[reply]
• yeast cells carry an additional silenced copy of both the MATa and MATα alleles I think you need to say this in the earlier MAT section. The reader is somewhat mislead until they get to this point.Czarking0 (talk) 18:30, 7 January 2025 (UTC)[reply]
• Hidden mating type loci are epigenetically silenced If they are epigentically silenced how is the DNA read into the active site when type switching occurs? Czarking0 (talk) 18:30, 7 January 2025 (UTC)[reply]
• Thus, meiosis and meiotic recombination may be an adaptation for repairing DNA damage. Is this meant to be a general statement or a statement about yeast, or a statement about this species?Czarking0 (talk) 18:30, 7 January 2025 (UTC)[reply]
• c. neoformans causes life-threatening meningoencephalitis in immunocompromised patients. out of scope. What is a filamentous transitionCzarking0 (talk) 18:30, 7 January 2025 (UTC)[reply]
• Both your special cases mention DNA repair as a motivating factor for meiosis. This some like something notable to address earlier in the article. Czarking0 (talk) 18:30, 7 January 2025 (UTC)[reply]
• Are the special cases meant to be an exhaustive list? It is sufficient to only have two? If it is not meant to be exhaustive then why are these two selected? Czarking0 (talk) 18:30, 7 January 2025 (UTC)[reply]
• Earwig has one significant finding but looking at it, I guess that they copied this article. Czarking0 (talk) 18:33, 7 January 2025 (UTC)[reply]
• I am concerned about the copyright status of Yeast Mating Types.png it seems to be uploaded as an excerpt from a copyrighted text. I nominated it for deletion
  • First, thanks for picking up this review after I got tied up in December with family matters! As the image's uploader, I have left a comment on the deletion nomination explaining my rationale to keep. In short, while the broader textbook is under copyright, this specific image is a simple diagram of a biological process that does not qualify for copyright protection. Commons:Threshold of originality#Charts explains this nicely with examples. ViridianPenguin 🐧 ( 💬 ) 21:37, 8 January 2025 (UTC)[reply]