Talk:Lupus

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Identical twin susceptibility/

In the intro it says a 24% concordance for identical twins; in the 'genetics' section it says 35%. Which is it, please? 110.141.141.172 (talk) 10:45, 30 August 2023 (UTC)[reply]

Semi-protected edit request on 15 October 2023

I recommend removing "Diagnostic criteria" There are no diagnostic criteria for systemic lupus There are only classification criteria, which are specifically for including patients into research studies. However, physicians often use the classification criteria to help guide their diagnoses of systemic lupus Resource for this suggestion: https://acrjournals.onlinelibrary.wiley.com/doi/epdf/10.1002/acr.22583

Aggarwal R, Ringold S, Khanna D, Neogi T, Johnson SR, Miller A, Brunner HI, Ogawa R, Felson D, Ogdie A, Aletaha D, Feldman BM. Distinctions between diagnostic and classification criteria? Arthritis Care Res (Hoboken). 2015 Jul;67(7):891-7. doi: 10.1002/acr.22583. PMID: 25776731; PMCID: PMC4482786.

After the line "Neurologic disorder: Seizures or psychosis; sensitivity = 20%; specificity = 98%.[86]" I recommend that the two newer classification be added in a manner similar to how the ACR criteria is already presented.

The two newer criteria are:

2012 SLICC criteria (use table 3 from this link:https://onlinelibrary.wiley.com/doi/10.1002/art.34473)

and

2019 ACR/EULAR criteria (use figure 2 from this link: https://assets.contentstack.io/v3/assets/bltee37abb6b278ab2c/blt78b4c1b38aa0039b/systemic-lupus-erythematosus-classification-criteria-complete-article-2019.pdf) Donthomasj (talk) 18:01, 15 October 2023 (UTC)[reply]

Not done: it's not clear what changes you want to be made. Please mention the specific changes in a "change X to Y" format and provide a reliable source if appropriate. Awhellnawr123214 (talk) 03:34, 2 November 2023 (UTC)[reply]

Famous case

Assyrian king Esarhaddon is suspected to have suffered from Lupus by Finnish Assyriologist Simo Parpola.

Parpola, Simo: Letters from Assyrian Scholars to the Kings Esarhaddon and Assurbanipal, 2007, p.232. https://www.google.de/books/edition/Letters_from_Assyrian_Scholars_to_the_Ki/JimYncnzaOkC?hl=de&gbpv=1&dq=Parpola+%22esarhaddon+as+systemic+lupus%22&pg=PA232&printsec=frontcover 2001:1A81:5396:6500:4901:9698:929E:832E (talk) 23:35, 4 January 2024 (UTC)[reply]

Wiki Education assignment: JUS 437 Justice and Disability The Social Construction of Disability

This article was the subject of a Wiki Education Foundation-supported course assignment, between 28 August 2024 and 20 November 2024. Further details are available on the course page. Student editor(s): Karminamontserrat (article contribs).

— Assignment last updated by Karminamontserrat (talk) 15:41, 13 October 2024 (UTC)[reply]

Semi-protected edit request on 9 December 2024

I suggest to add two sentences to the information under the "Sex" heading which is under "Epidemiology" for Lupus, which would speak to new research discoveries focused on age-associated B cells and their relation to the female bias in lupus. Here are the two sentences I suggest, including their citations:

Age-associated B cells, a type of B cell that typically increase as people age, proliferate at an earlier age in people with an autoimmune disease such as lupus.^[1] A study has shown the dysfunction of age-associated B cells may be a contributor to the female bias of lupus^[2] due to a gene on the X-chromosome that is also known to escape silencing by X-chromosome inactivation, TLR7.^[3] Brielle White (talk) 00:42, 9 December 2024 (UTC)[reply]

^ Sachinidis, A., Xanthopoulos, K., & Garyfallos, A. (2020). Age-Associated B Cells (ABCs) in the Prognosis, Diagnosis and Therapy of Systemic Lupus Erythematosus (SLE). Mediterranean journal of rheumatology, 31(3), 311–318. https://doi.org/10.31138/mjr.31.3.311
^ Ricker, E., Manni, M., Flores-Castro, D., Jenkins, D., Gupta, S., Rivera-Correa, J., Meng, W., Rosenfeld, A. M., Pannellini, T., Bachu, M., Chinenov, Y., Sculco, P. K., Jessberger, R., Prak, E. T., & Pernis, A. B. (2021). Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-25102-8
^ Souyris, M., Cenac, C., Azar, P., Daviaud, D., Canivet, A., Grunenwald, S., Pienkowski, C., Chaumeil, J., Mejía, J. E., & Guéry, J. C. (2018). TLR7 escapes X chromosome inactivation in immune cells. Science immunology, 3(19), eaap8855. https://doi.org/10.1126/sciimmunol.aap8855

[1] Sachinidis, A., Xanthopoulos, K., & Garyfallos, A. (2020). Age-Associated B Cells (ABCs) in the Prognosis, Diagnosis and Therapy of Systemic Lupus Erythematosus (SLE). Mediterranean journal of rheumatology, 31(3), 311–318. https://doi.org/10.31138/mjr.31.3.311

[2] Ricker, E., Manni, M., Flores-Castro, D., Jenkins, D., Gupta, S., Rivera-Correa, J., Meng, W., Rosenfeld, A. M., Pannellini, T., Bachu, M., Chinenov, Y., Sculco, P. K., Jessberger, R., Prak, E. T., & Pernis, A. B. (2021). Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-25102-8

[3] Souyris, M., Cenac, C., Azar, P., Daviaud, D., Canivet, A., Grunenwald, S., Pienkowski, C., Chaumeil, J., Mejía, J. E., & Guéry, J. C. (2018). TLR7 escapes X chromosome inactivation in immune cells. Science immunology, 3(19), eaap8855. https://doi.org/10.1126/sciimmunol.aap8855

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