TSPAN32

TSPAN32
Identifiers
Aliases	TSPAN32, ART1, PHEMX, PHMX, TSSC6, tetraspanin 32
External IDs	OMIM: 603853; MGI: 1350360; HomoloGene: 10650; GeneCards: TSPAN32; OMA:TSPAN32 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	2,318,204 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	142,573,381 bp
RNA expression pattern
	Top expressed in
	Top expressed in
	More reference expression data
	More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
	Sources:Amigo / QuickGO
Orthologs
	10077
	27027
	ENSG00000064201
	ENSMUSG00000000244
	Q96QS1
	Q9JHH2
	NM_005705; NM_139022; NM_139024
	NM_001128080; NM_001128081; NM_001128082; NM_020286
	NP_620591
	NP_001121552; NP_001121553; NP_001121554; NP_064682
	Wikidata
View/Edit Human	View/Edit Mouse

Tetraspanin-32 is a protein that in humans is encoded by the TSPAN32 gene.^[5]^[6]^[7]

Function

This gene is described as a member of the tetraspanin superfamily whose expression is confined to hematopoietic tissues.^[7]

Clinical significance

This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is located among several imprinted genes; however, this gene, as well as the tumor-suppressing subchromosomal transferable fragment 4 (TSSC4), escapes imprinting. This gene may play a role in malignancies and disease that involve this region as well as hematopoietic cell function.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000064201 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000244 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lee MP, Brandenburg S, Landes GM, Adams M, Miller G, Feinberg AP (Apr 1999). "Two novel genes in the center of the 11p15 imprinted domain escape genomic imprinting". Hum Mol Genet. 8 (4): 683–90. doi:10.1093/hmg/8.4.683. PMID 10072438.
^ Nicholson RH, Pantano S, Eliason JF, Galy A, Weiler S, Kaplan J, Hughes MR, Ko MS (Sep 2000). "Phemx, a novel mouse gene expressed in hematopoietic cells maps to the imprinted cluster on distal chromosome 7". Genomics. 68 (1): 13–21. doi:10.1006/geno.2000.6277. PMID 10950922.
^ ^a ^b ^c "Entrez Gene: TSPAN32 tetraspanin 32".

External links

TSPAN32 human gene location in the UCSC Genome Browser.
TSPAN32 human gene details in the UCSC Genome Browser.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000064201 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000244 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10072438-5] Lee MP, Brandenburg S, Landes GM, Adams M, Miller G, Feinberg AP (Apr 1999). "Two novel genes in the center of the 11p15 imprinted domain escape genomic imprinting". Hum Mol Genet. 8 (4): 683–90. doi:10.1093/hmg/8.4.683. PMID 10072438.

[pmid10950922-6] Nicholson RH, Pantano S, Eliason JF, Galy A, Weiler S, Kaplan J, Hughes MR, Ko MS (Sep 2000). "Phemx, a novel mouse gene expressed in hematopoietic cells maps to the imprinted cluster on distal chromosome 7". Genomics. 68 (1): 13–21. doi:10.1006/geno.2000.6277. PMID 10950922.

[entrez-7] "Entrez Gene: TSPAN32 tetraspanin 32".

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[2]

[3]

[4]

[5]

[6]

[7]

Protein: cell membrane proteins (other than Cell surface receptor, enzymes, and cytoskeleton)
Arrestin	SAG ARRB1 ARRB2 ARR3
Membrane-spanning 4A	MS4A1 MS4A2 MS4A3 MS4A4A MS4A4E MS4A5 MS4A6A MS4A6E MS4A7 MS4A8B MS4A9 MS4A10 MS4A12 MS4A13 MS4A14 MS4A15 MS4A18
Myelin	Myelin basic protein PMP2 Myelin proteolipid protein PLP1 Myelin oligodendrocyte glycoprotein Myelin-associated glycoprotein Myelin protein zero
Pulmonary surfactant	Pulmonary surfactant-associated protein B Pulmonary surfactant-associated protein C
Tetraspanin	TSPAN1 TSPAN2 TSPAN3 TSPAN4 TSPAN5 TSPAN6 TSPAN7 TSPAN8 TSPAN9 TSPAN10 TSPAN11 TSPAN12 TSPAN13 TSPAN14 TSPAN15 TSPAN16 TSPAN17 TSPAN18 TSPAN19 TSPAN20 TSPAN21 TSPAN22 TSPAN23 TSPAN24 TSPAN25 TSPAN26 TSPAN27 TSPAN28 TSPAN29 TSPAN30 TSPAN31 TSPAN32 TSPAN33 TSPAN34
Other/ungrouped	Calnexin LDL-receptor-related protein-associated protein Neurofibromin 2 Presenilin PSEN1 PSEN2 HFE Phospholipid transfer proteins Dysferlin STRC OTOF
see also other cell membrane protein disorders

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