Spyder may refer to:

• Spyder, a minor Myth Adventures character
• Spyder (film), a 2017 Indian film directed by A. R. Murugadoss, starring Mahesh Babu
  • Spyder (soundtrack), its soundtrack by Harris Jayaraj
• Spyder Games, an MTV television series
• Spyder (song), a 1996 Imperial Drag song off their album Imperial Drag (album)
• SPYDER, the villain in the book series Spy School by Stuart Gibbs

• Roadster (automobile), a type of car
• Several cars made by Porsche:
  • Porsche 550 Spyder, a very successful race-purpose car from the 1950s
  • Porsche RS Spyder, an LMP2 racing car from 2005-2010, named in tribute to the Porsche 550 Spyder
  • Porsche 918 Spyder, a high performance plug-in hybrid sports car from 2013-2015
  • Porsche 718 Spyder (previously named the Boxster Spyder), mid-engine roadster from 2019-2024
• Chevrolet Corvair Monza Spyder, a turbocharged version of the Chevrolet Corvair
• Chevrolet Monza Spyder, a performance package version of the 1975–1980 subcompact, four-passenger automobile
• Lamborghini Gallardo Spyder, a production model of the Lamborghini Gallardo
• Mitsubishi 3000GT Spyder, a 2-door hard top convertible version of the Mitsubishi 3000 GT
• Mitsubishi Eclipse Spyder, a 2-door convertible version of the Mitsubishi Eclipse
• BRP Can-Am Spyder Roadster, a three-wheeled motor vehicle manufactured by Can-Am
• Toyota Spyder, a convertible sold in the United States
• Maserati Spyder, a grand tourer

• Spyder Turner (born 1947), American soul singer
• Spyder Jonez, screen name of pornographic actor Evan Seinfeld
• Joe "Spyder" Lester, current bassist for the American rock band Steel Panther

• SPYDER, an anti-aircraft missile-system
• Spyder (software), an open-source IDE for the Python programming-language
• Spyder, codename for the Motorola Droid Razr, an Android smartphone

• Spyder (ski apparel brand)

• Spider (disambiguation)
• SPDR (disambiguation)