Spencer-Churchill is a British double-barrelled surname of a British noble family associated with the Marlborough dukedom.

• Lord Alan Spencer-Churchill (1825–1873), British Army officer
• Albertha Spencer-Churchill, Duchess of Marlborough (1847–1932), English aristocrat
• Lord Alfred Spencer-Churchill (1824–1893), British politician
• Anne Innes-Ker, Duchess of Roxburghe (née Spencer-Churchill; 1854–1923)
• Charles Spencer-Churchill (disambiguation), multiple people
• Clarissa Spencer-Churchill (1920–2021), wife of Anthony Eden
• Sir Winston Spencer Churchill (1874-1965), prime minister of the UK
• Clementine Churchill (1885–1977), life peer and wife of Winston Churchill
• Frances Anne Spencer-Churchill, Duchess of Marlborough (1822–1899), English noblewoman
• George Spencer-Churchill (disambiguation), multiple people
• Gladys Spencer-Churchill, Duchess of Marlborough (1881–1977), French-American socialite
• Lady Henrietta Spencer-Churchill (born 1958), English interior decorator
• Lord Ivor Spencer-Churchill (1898–1956), British peer
• Jane Spencer-Churchill, Duchess of Marlborough (1798–1844)
• James Spencer-Churchill, 12th Duke of Marlborough
• John Spencer-Churchill (disambiguation), multiple people
• Laura Spencer-Churchill, Duchess of Marlborough (1915–1990), British noblewoman and socialite
• Lily Spencer-Churchill, Duchess of Marlborough (1854–1909), American socialite
• Lady Norah Beatrice Henriette Spencer-Churchill (1875–1946), English aristocrat
• Randolph Spencer Churchill (disambiguation), multiple people
• Lady Rosemary Spencer-Churchill (born 1929), maid of honour to Elizabeth II at her coronation
• Rosita Spencer-Churchill, Duchess of Marlborough (born 1943), British artist
• Susan Spencer-Churchill, Duchess of Marlborough (1767–1841)

• Lady Spencer-Churchill College, now part of Oxford Brookes University

• List of people with surname Spencer
• Churchill (surname)
• All pages with titles containing Spencer-Churchill