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Albino bias refers to the societal prejudice and discrimination against people with albinism and, in particular, the negative depiction of people with albinism in the mass culture. Research has established that people with albinism are not physically or mentally different from other people, apart from differences in pigmentation and vision.

One of the oldest perceived examples of albino bias was H.G. Wells's depiction of the main character in his 1897 science-fiction novel The Invisible Man. The character was able to become invisible using his scientific discoveries only because he already lacked natural pigmentation; he subsequently became mentally deranged, thus creating the stereotyped image of the albino villain or the albino madman.

More than a century later, albino bias has persisted in the literature and movies. For example, the 2003 Warner Bros movie The Matrix Reloaded featured two sociopathic characters with white skin and white hair (whom their creators have said are not albinos but are pale and white because they are like ghosts). Positive depictions of albinos in mass culture are rare, though one example is the 1995 film Powder which depicts an exceptionally gifted young albino and the cruelty he endures because of his differences from "normal" people. In recent years, the National Organization for Albinism and Hypopigmentation (NOAH) has spoken out against albino bias in the United States.

The following movies have been criticized for albino bias, as they associate the uncommon features of albino people (pale skin, yellow or white hair, and pale or pink eyes) with danger, terror, ridicule, maladjustment, or criminality:

• The Da Vinci Code (2006)
• Cold Mountain (2003)
• The Matrix Reloaded (2003)
• The Time Machine (2002)
• Not Another Teen Movie (2001)
• Me, Myself and Irene (2000)
• End of Days (1999)
• Disturbing Behavior (1998)
• Treehouse of Horror VIII (The Simpsons Halloween Special) (1997)
• Powder (1995)
• Star Trek: Deep Space Nine – Blood Oath (1994)
• The Firm (1993)
• Lethal Weapon (1987)
• The Princess Bride (1987)
• Vamp (1986)
• Stick (1985)
• Foul Play (1978)
• Albino (1976)
• The Eiger Sanction (1975)
• The Life and Time of Judge Roy Bean (1972)
• The Omega Man (1971)

• Evil Albino

• NOAH, National Organization for Albinism and Hypopigmentation