Notable followers of the Syro-Malabar Catholic Church include:

(In chronological order)

• Parambil Chandy Malpan (Malpan 1663-87)
• Joseph Kariattil (Appointed in 1782)
• Paremmakkal Thoma Kathanar (Appointed in 1786)
• Mar Abraham Pandari(Poulose)(Appointed in 1798)
• Palackal Thoma Malpan (1780–1841)
• Kuriakose Elias Chavara (1805–71)
• Nidhiry Mani Kathanar (1842–1904)
• Aloysius Pazheparambil (1847–1919)
• Thomas Kurialachery (1873–1925)
• Augustine Kandathil (1874–1956): First Head of the Syro-Malabar Church after the restoration of Hierarchy

• Varghese Payyappilly Palakkappilly (1876–1929)
• Joseph C. Panjikaran (1888-1949)
• Thevarparampil Kunjachan (Kunjachan) (1891–1973)
• St. Alphonsa of India (1910–46)
• Euphrasia Eluvathingal (1877-1952)
• Joseph Parecattil (1912–87)
• Antony Padiyara (1921–2000)
• Varkey Vithayathil (1927–2011)
• Abraham Kattumana (1944–1995)

(In chronological order)

• Thoma of Villarvattom (c. 15th century CE): The only Christian King in the history of the Indian sub-continent.
• Thachil Matthoo Tharakan
• C. J. Varkey, Chunkath - Minister of Madras Presidency (1939).^[1]
• A. J. John, Anaparambil (1893–1957): Chief Minister of Travancore-Cochin (1951–53) and Governor of Madras.^[1]
• P. T. Chacko, Pullolil - Member of Indian Constituent Assembly from Travancore (1949–50), and Home Minister of Kerala (1960–64).^[1]
• P. J. Thomas, Parakunnel - first Economic Advisor of independent India and Member of the Rajya Sabha, Upper house of Indian Parliament (1957-1962)

(In chronological order)

• Paremmakkal Thoma Kathanar - Author of the first travelogue in an Indian language (1778)^[2]

Laymen chosen as Papal Dignitaries for their meritorious service to the Church and to society:-

• George Menachery, Ollur (2008)