A strange man who is the uncle and grandfather of everyone in the world must do battle with a gang of mutants, after an attempt to build a supercomputer to gain the appreciation and love of his favorite nephew goes awry.
Note: Before the advent of the show of the same name, this same pilot was used as "the basis" for the 2011 TV series Secret Mountain Fort Awesome.^{[clarification needed]}

Uncle Grandpa shows up at a lame birthday party and tries to make it cool.

Note: Was shown as the 16th episode of Secret Mountain Fort Awesome.

Dingle steals Ham Sandwich (from Uncle Grandpa's 2008 pilot) and gives him to Festro for his birthday.

When the kid named Benny (voiced by Zachary Gordon) experiences difficulties with putting on his shirt due to his big belly getting in the way, Uncle Grandpa tries to make it up to him by going inside a Night Wolf shirt and teaching him about the benefits of having a big belly.

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Short: "A Slice of Life with Pizza Steve: Speed Cycle"

When Giant Realistic Flying Tiger fails to show up during a wizard battle, Uncle Grandpa and his friends follow her trail in order to find out where she went.

• Special guest stars: Jonathan Adams as Caleb, and Rob Schrab as Evil Wizard.

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Short: "Fishing with Uncle Grandpa"

After accidentally sending Melvin (voiced by Jarid Root) who thinks he's a space emperor to an alternate dimension, Uncle Grandpa comes to the rescue.

• Special guest stars: Jarid Root as Melvin, and Tim Blaney as Emperor Krell.

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Short: "Tiger Talk: Interview with Mr. Gus"

Only Mr. Gus can save the day when a funny face head Uncle Grandpa created takes on a life of its own and starts to wreak havoc in the RV.

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Short: "New Experiences with Beary Nice & Hot Dog Person: Ice Cream"

Uncle Grandpa and friends are in a rush to get some emergency moustache cream.

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Short: "Uncle Grandpa Changes a Lightbulb"

Uncle Grandpa helps a kid called Eric earn his nickname with some intense yard work.

• Special guest star: Jarid Root as Spaghetti Legs.

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Short: "Mr Gus' Breakdance"

Uncle Grandpa helps Mary (voiced by Pamela Adlon) earn her drivers' license by showing her how to drive the RV.

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Short: "A Slice of Life with Pizza Steve: Hare Brush"

Uncle Grandpa creates a duplicate of himself to babysit him while his friends go out for ice cream.

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Short: "New Experiences with Beary Nice & Hot Dog Person: Tree Climbing"

After Uncle Grandpa eats Dennis' diorama of the Pyramids of Egypt, he tries to make it up to him by bringing a real-life mummy to school.

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Short: "Tiny Miracle the Robot Boy"

After Uncle Grandpa and Belly Bag get stuck in peanut butter jars, it's up to Pizza Steve, and Mr. Gus to give a boy named Guillermo a new bike.

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Short: "Uncle Grandpa Sings the Classics"

Uncle Grandpa helps Susie overcome her fear of the dark.

Uncle Grandpa, Belly Bag, Mr. Gus, and Pizza Steve follow the map of a kid's menu to find treasure to pay for their meal.

Uncle Grandpa and Belly Bag get locked out of the RV, and must get back so them and Mr. Gus, Pizza Steve and GRFT can go on their mystery dates.

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Short: "Xarna, She-Warrior of the Apocalypse: Part 1"

To avoid being laughed at, Mr. Gus tries to get his skin tight jean-shorts off before everyone sees him.

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Short: "A Slice of Life with Pizza Steve: Pizza Party"

Uncle Grandpa and Pizza Steve control Adam's (voiced by Dee Bradley Baker) brain to help him become a video game master.

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Short: "Uncle Grandpa's Story Time Storybook of Stories: The Legend of the Beardman: The Nighttime Tickler"

Uncle Grandpa and friends try to find a strange noise that's keeping them all awake.

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Short: "Tiger Talk: Roommate Problems"

Uncle Grandpa and his friends helps a dog named Charlie Burgers get his lost ball back.

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Short: "Mr. Gus' Work Out"

As the title says, this episode is entirely divided into three shorts, and they are:
1) Good Morning News: Uncle Grandpa and friends host a news program.
2) Cool or Dumb?: Tortoises make decisions on what is cool or dumb.
3) Uncle Grandpa in Piñata: Uncle Grandpa goes on an accidental rampage while trying to crack open a piñata.

Uncle Grandpa turns Austin (voiced by Carlos Alazraqui) into a robot so he can be perfect.

• Special guest star: Shaquille O'Neal as himself.

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Short: "UG Rap Attack"

Uncle Grandpa and friends travel to Japan to help Akira (voiced by Jessika Van) make an action-packed monster movie.

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Short: "A Slice of Life with Pizza Steve: Car Radio"

Uncle Grandpa and Mr. Gus leg wrestle to decide what to watch on TV.

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Short: "Evil Wizard" (voiced by Rob Schrab)

Future Uncle Grandpa arrives with a warning that stresses out Pizza Steve.

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Short: "Board Game Night"

This episode, like the 18th, is entirely divided into three more shorts, and they are:
1) Homez: Uncle Grandpa gives a tour of the UG-RV.
2) Weird Man: Uncle Grandpa reads his new comic of Weird Man.
3) Italian Karate Tournament: Pizza Steve tells the story of how he won the Italian Karate Tournament.

Uncle Grandpa hosts a blank episode for one lucky viewer (voiced by Jon Heder) to decide what the gang's next adventure will be.

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Short: "Xarna, She-Warrior of the Apocalypse: Part 2"

When Uncle Grandpa gets out from the wrong side of his bed and says "bad morning" instead of "good morning", Mr. Gus, Pizza Steve, and Giant Realistic Flying Tiger attempt to lift Uncle Grandpa's spirits up.

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Short: "E-mail the Duck"

Mr. Gus pulls a prank that leaves Pizza Steve in danger of being eaten.

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Short: "Uncle Grandpa Cooks a Burrito"

Uncle Grandpa had sent a pair of pants back in time to 1492 but the pants were suppose to go to 1992, but Christopher Columbus wouldn't give the pants back, and if Uncle Grandpa and Pizza Steve don't get the pants back by the end of the day, 1992 would call the time police on Uncle Grandpa.

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Short: "Shave Time"

After Uncle Grandpa misunderstood Pizza Steve when he was talking in the third person, he sends Pizza Steve to the moon (voiced by Tone Loc) so, Uncle Grandpa could be Pizza Steve's best friend.

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Short: "Ghost Math"

Pizza Steve had set a goal to raise $13 million to get a jet he fantasized about, so he convinces Uncle Grandpa to start a food truck and sell burger dogs so Pizza Steve could have his jet.

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Short: "Moments in History with Mr. Gus"

The gang tries to show Uncle Grandpa that hide and seek is not a evil game, but things take a turn for the worst when Uncle Grandpa can't find his friends just like how he couldn't find his old friend Skeletony (Tony) (voiced by Henry Rollins).

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Short: "Bubble Trouble"

A documentary about one of the nuttiest wrestling matches to ever go down in history, showing how Chicken Man, The Best, and Mysterious Gus won all of their matches to make it the nuttiest wrestling match to ever happen in history.

• Special guest stars: Ric Flair as himself, and Jon Heder as Kev.

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Short: "New Experiences with Beary Nice and Hot Dog Person: Imaginations"

After a failed attempt to give Uncle Grandpa his laser hammer, Uncle Grandpa must go inside of Belly Bag to see why he's not feeling so hot.

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Short: "Game of Tag"

Uncle Grandpa is exhausted from helping all the time, and decides to go on vacation, only to find that being Uncle Grandpa is a full-time responsibility.

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Short: "Tiger Talk: Cooking with Frankenstein"

Uncle Grandpa has to try to stop Aunt Grandma (voiced by Lena Headey) before she makes everyone forget about Uncle Grandpa. Aunt Grandma only wants to make Uncle Grandpa obsolete so that he could stop taking kids on pointless adventures.

Uncle Grandpa helps a teen named Riley (voiced by Scott Menville) go to a party only to realize that he has been grounded.

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Short: "Uncle Grandpa Babies"

For Halloween, Uncle Grandpa throws a haunted house in the RV, a couple of teenagers decide to go first in the RV since every other haunted house didn't scare them. Once they see that Uncle Grandpa's haunted RV isn't scary, Uncle Grandpa improves the haunted RV by putting Frankenstein's brain under the hood of the RV, and it turns the whole RV into a haunted house filled with monsters and the haunted house keeps the teenagers captive, so Uncle Grandpa and friends must go in and save the trapped teenagers.

Uncle Grandpa uploads a video of himself walking on hot dogs onto the internet, and notices that someone didn't like the video. Mr. Gus tells Uncle Grandpa that the guy is just an internet troll, but Uncle Grandpa suspects that the guy might be a real troll in disguise, and vows to slay the troll.

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Short: New Experiences with Beary Nice and Hot Dog Person: Haircuts

Uncle Grandpa tries to make a girl named Jacklin laugh at his jokes, but Jacklin thinks that the jokes aren't funny, so when Uncle Grandpa sees what's going on in her body, he sees a bunch of monsters inside of her as a result of laughing on the inside.

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Short: Grandpa Cize

When Pizza Steve and Mr. Gus accidentally start to prank phone call on a intergalactic phone, they immediately get thrown in intergalactic jail and they must work together to escape.

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Short: UG-RV Check Up

After a shopping spree at the mall, Mr. Gus heads down to his favorite shop by taking the stairs down, Pizza Steve and Uncle Grandpa decide to take the escalator down, on the way down the escalator stops working and people start panicking that they're stuck on a broken escalator which causes a pandemic around the world.

When Uncle Grandpa crashes into the North Pole, he must help Santa deliver the presents and save Christmas. Uncle Grandpa learns how his friends would've lived if he didn't exist.

Uncle Grandpa turns into a dog to teach a girl named Sandy how to be a responsible pet owner.

When a Giant Realistic Flying Tiger chases a mouse around the RV, Uncle Grandpa forces them to be friends but he has to face with the problem of the mouse destroying things in the RV along with Giant Realistic Flying Tiger.