Some of the Prominent Syro-Malabar Catholics in History are listed here (living personalities are not included):

(In chronological order)

• Parambil Chandy Malpan (Malpan 1663-87)
• Mar Joseph Kariattil (Appointed in 1782)
• Gubernadore Paremmakkal Thoma Kathanar (Appointed in 1786)
• Palackal Thoma Malpan (1780–1841)
• Blessed Kuriakose Elias Chavara (1805–71)
• (Karottu) Peediakal Mathew Ouseph Malpan (1840--1897)Vicar of st Marys Forane church Athirampuzha (own parish) for 24 consecutive years (1873-1897) a record in Indian church history
• Palakunnel Mathai Mariam Kathanar- Valiyachen (1833–1900)Is called as the Subhash chandra Bose of Sabha Charithram- founder of Erumely koratty Church, Koothrappally church- was the spiritual adviser of Puthenparambil Thomachen ( servant of God)and served Meloose as the Vicar General for short period.
• Nidhiry Mani Kathanar (1842–1904)
• Mar Louis Pazheparambil (1847–1919)
• Servant of God Mar Thomas Kurialachery (1873–1925)
• Mar Augustine Kandathil (1874–1956): First Head of the Syro-Malabar Church

• Servant of God Mar Varghese Payyappilly Palakkappilly (1876–1929)
• Mgr. Joseph C. Panjikaran (1888-1949)
• Thevarparampil Kunjachan (Kunjachan) (1891–1973)
• St. Alphonsa of India (1910–46)
• Euphrasia Eluvathingal (1877-1952)
• Servant of God Mar Mathew Kavukatt(1905–69)
• Mar Joseph Parecattil (1912–87)
• Mar Antony Padiyara (1921–2000)
• Mar Varkey Vithayathil (1927–2011)
• Mar Jonas Thaliath (1919–1981) Founder - Dharmaram College, Bangalore
• Mar Abraham Kattumana (1944–1995)
• Father Placid J Podipara (1899–1985)

(In chronological order)

• Thoma of Villarvattom (c. 15th century CE): The first and only Christian King in the history of the Indian sub-continent.
• Thachil Matthoo Tharakan (1741–1814): Minister of Travancore of a Princely State in India.
• Ezhupunna Parayil Avira Varkey Tharakan - Founder President (1905) of All Kerala Catholic Congress, the leading organization of Catholic laity.
• Elanjickal Thariath Kunjithommen - Legislator (1932) who first espoused the cause of Syrian catholic community (also, President, All Kerala Catholic Congress).
• C. J. Varkey, Chunkath - Minister of Madras Presidency (1939).
• A. J. John, Anaparambil (1893–1957): Chief Minister of Travancore-Cochin (1951–53) and Governor of Madras.
• Cyriac Kandathil - Organiser (1932) and General Secretary (1945), All Kerala Catholic Congress, and Editor, Keraladeepam.
• R. V. Thomas - President (Speaker) of Travancore Legislative Assembly (1948–50) and Member of Indian Constituent Assembly from Travancore (1949–50).
• Prof. K. M. Chandy(1921-1998), Freedom fighter(1942-1947), Former L. Governor of Pondicherry(1982), former Governor of Gujarat(1983-1984), Madhya Pradesh,legislator, Former KPCC President(1967-1972), Professor St. Thomas College Pala (Reformer
• P. T. Chacko, Pullolil - Member of Indian Constituent Assembly from Travancore (1949–50), and Home Minister of Kerala (1960–64).
• Joseph Mundassery (1903–77): Literary Critic and Social Reformer (First Education Minister of Kerala).
• George Thomas Kottukapally United Nations (U.N.) Delegate of India, Member of Parliament of Meenachil district
• K. M. George (19..-76): Founder Member Kerala Congress and Minister in Kerala Govt.
• Parambi Lonappan - Minister of Cochin State (1945).
• A. C. George (19..-80): Minister in Government of India.
• K M Mani :Longest serving minister and longest serving member of Kerala Assembly.
• P J Joseph :Kerala Congress Leader and minister.
• P C George :Kerala Congress Leader.

(In chronological order)

• Justice Thaliath - Chief Justice of Travancore State.
• Dr Jacob Thaliath - Surgeon General of Travancore State.
• P. J. Thomas, Parakunnel (1895–1965): First Economic Advisor of Government of India.
• K. K. Mathew (1911–92): First Christian Justice of the Supreme Court of India.
• Engineer P K Thresia - First Woman Chief Engineer of Kerala.
• Rev.Dr.Matthew Pothen Thekaekara- Eminent Spectroscopist associated with the Thekaekara spectrum

(In chronological order)

• Paremmakkal Thoma Kathanar - Author of the first travelogue in an Indian language (1778).
• Nidhiry Mani Kathanar (1842–1904): Founder Editor of Deepika, the oldest Malayalam Daily.
• Mahakavi Kattakayam Cherian Mappillai (1859–1936): Poet and Editor of Literary Magazine
• I. C. Chacko, Illiparambil (1875–1966): Writer & Grammarian and one of the early recipients of the Kerala Sahitya Academy Award
• Sr. Mary Benigna (1899–1985): Poet
• Joseph Mundassery (1903–77): Literary Critic and Social Reformer (later Education Minister of Kerala).
• M P Paul (1904–52): Writer and Literary Critic
• Mathew M. Kuzhively - The author of the first Encyclopedia in an Indian Language.
• V C George Church Historian
• K E Job - Church Historian, Educationlist and Text Book Writer
• Mahakavi P. C. Devassia (1906–2006) :Sanskrit scholar and poet who won the Sahitya Akademi Award (1980) for Sanskrit for his poem Kristubhagavatam.
• Mutthathu Varkey- Author
• Abraham Verghese: Physician and author of award-winning novel Cutting for Stone

(In chronological order)

• Thachil Mathoo Tharakan (1741–1814): First timber exporter of South India
• Joseph Augusti Kayalackakom (1884–1968): Founder of Palai Central Bank.
• George Joseph Kottukapally - Director of Palai Central Bank and Sree Moolam Prajha Sabha Member
• George Thomas Kottukapally - Member of Parliament, recorded as the largest individual Syrian Christian landholder in history with over 13,000 acres
• Kunchacko Maliampurackal (1912–84): Founder of Udaya Studios, and pioneer of Malayalam Film industry.
• Kulangara Paulo Hormis (1917-..): Founder of Federal Bank.
• Dominic Chacko (DC) Kizhakkemuri (1914–99): Foremost book publisher in Malayalam Language.
• Chakola Lonappan Palu - Leader in Textile Trade & Industry.
• Dominic Joseph Kuruvinakunnel (1921–2007): Founder of Casino (CGH Earth) Group of Hotels and Father of Tourism Industry in Kerala.

(In chronological order)

• P J Cherian (1891–1981): Artist and Drama Actor
• Rajan P Dev : Film Artist and Drama Actor
• Alummoodan : Film Artist and Drama Actor
• Philomina : Film Artist and Drama Actor
• Meena : Film Artist and Drama Actor
• C I Paul : Film Artist and Drama Actor
• Fr. Abel Periyappuram (1920–2001): Founder of Kalabhavan.
• Miss Kumari (1932–69)
• Jimmy George (1955–87): International Volleyball Player.

Laymen chosen as Papal Dignitaries for their meritorious service to the Church and to society:-

Pro Ecclesia et Pontifice

• Thomas Manjooran, Ernakulam (1936)
• Lona Vareed Kanjirakat Thachil, Kuthiathode (1936)
• George Chakkalakal, Perumanoor (1951)
• V.D. Ouseph, Vellanikaren, Ernakulam
• A.V. Moothedan Ernakulam (1952)
• Dr. P.M. Joseph, Ernakulam (1954)
• Joseph Kunjavaran, Kunnathottathil, Kottamam (1965)

Knight of St Gregory (Chevalier)

• Parayil Varkey Avara Tharakan, Ezhupunna
• Lona Vareed Kanjirakat Thachil, Kuthiathode (1952)
• Chakola Palu Lonappan, Trichur
• Ayyanattuparayil Kunjavara Tharakan, Thycattussery
• A.C.M. Anthraper, Cherthala (1952)
• Justice Joseph Vithayathil, Ernakulam
• K V Zacharia, Pottamkulam, Manjappally
• Artist P.J. Cherian Puthenangady, Ernakulam (1965)
• Joseph Pettah
• K.C. Chacko Kadankavil, Edappally (1969)
• George Menachery, Ollur (2008)

Privy Chamberlain

• Justice Joseph Vithayathil, Ernakulam (1964)