Reelin: Difference between revisions
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CopperKettle (talk | contribs) Added some links. Added the wikilink to the newly created DAB1 article |
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The primary phenotype associated with loss of reeler function is inverted cortex. Inverted cortex is a neuroanatomical defect in which the six cortical layers are inverted. In humans inverted cortex is associated with severe mental retardation and epilipsy. |
The primary phenotype associated with loss of reeler function is inverted cortex. Inverted cortex is a neuroanatomical defect in which the six cortical layers are inverted. In humans inverted cortex is associated with severe mental retardation and epilipsy. |
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[[Heterozygous]] mice for the reelin gene had very little obvious neuroanatomical defect but those that they had resembled the changes of the human [[schizophrenic]] brain. A special stain for the reelin protein showed a similar pattern of reelin deficiency in heterozygotic reeler mice, and also in biopsies of brains of psychotic patients. |
[[Heterozygous]] mice for the reelin gene had very little obvious neuroanatomical defect but those that they had resembled the changes of the human [[schizophrenic]] brain. A special stain for the reelin protein showed a similar pattern of reelin deficiency in heterozygotic reeler mice, and also in biopsies of brains of psychotic patients. |
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In the reelin signaling pathway, the other major participant is the intracellular protein [[DAB1]]. |
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Research into its functions and the causes and clinical effects of deficiencies is continuing. |
Research into its functions and the causes and clinical effects of deficiencies is continuing. |
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== Links == |
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[http://www.biocarta.com/pathfiles/h_reelinPathway.asp Reelin Signaling Pathway] |
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[http://www.jcb.org/cgi/content/full/159/1/15-b The real role of reelin] - publication in The Journal of Cell Biology, 2002 |
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Revision as of 09:11, 14 May 2006
Reelin is a protein found in the brain.
Its name comes from the abnormal reeling gait of reeler mice, which were found to have a deficiency of this brain protein and were homozygous for the reelin gene. The primary phenotype associated with loss of reeler function is inverted cortex. Inverted cortex is a neuroanatomical defect in which the six cortical layers are inverted. In humans inverted cortex is associated with severe mental retardation and epilipsy. Heterozygous mice for the reelin gene had very little obvious neuroanatomical defect but those that they had resembled the changes of the human schizophrenic brain. A special stain for the reelin protein showed a similar pattern of reelin deficiency in heterozygotic reeler mice, and also in biopsies of brains of psychotic patients. In the reelin signaling pathway, the other major participant is the intracellular protein DAB1.
Research into its functions and the causes and clinical effects of deficiencies is continuing.
Links
The real role of reelin - publication in The Journal of Cell Biology, 2002