Jerk may refer to one of the following:

• Jamaican jerk spice, a style of cooking native to Jamaica in which meats are dry-rubbed with a fiery spice mixture
• The second phase of the "clean and jerk", a weightlifting exercise
• Hypnic jerk, an involuntary muscle twitch during the transition from wakefulness to sleep
• Soda jerk, a person who operates a soda fountain
• Jerk (physics), in physics, the rate of change of acceleration
• The Jerk (1979), a comedy film starring Steve Martin
• "The Jerk" (House episode), a third season episode of the TV series House
• Jerk, an album released in 1995 by hHead on IRS records
• Jerk (band), an industrial metal band from Sydney, Australia
• The Jerk (dance), a 1960s dance craze