Blockbuster is a fictional character appearing in DC Comics. The first one was primarily a foe of Batman and Robin, while the second frequently fought Nightwing.

The first Blockbuster was Mark Desmond, a chemist who wanted to become stronger. Experimenting on himself, he grew stronger and taller, but in the process was turned into a mindless brute. Desmond was cared for by his ciminally-minded brother, Roland, who shielded Mark's monstrous appearance from their mother.

Roland used Mark to commit crimes until they were stopped by Batman and Robin. Desmond had years earlier been rescued from drowning by Bruce Wayne, and the Dark Knight Detective discovered that he could calm and stall the behemoth by removing his cowl and revealing his face. The sight did indeed calm the giant, preventing further destruction. Blockbuster sought solitude when free, only to find himself opposing the Capred Crusader on various occassions. He was recruited by Amanda Waller's new Suicide Squad, and died battling Darkseid's creation Brimstone.

After the gene bomb detonation during the alien Invasion!, Mark's brother Roland found he was now a child-minded superstrong behemoth. He went on a rampage, but Batman and Starman ensured that he wound up behind bars.

Acquiring a genius-level intellect became Desmond's obsession, and the demon Neron made it a reality. Selling his soul to the demon, he obtained aweseom acumen that matched his phenomenal physical power. Setting up shop in his mother's home of Blüdhaven, Desmond forced out crimelord Angel Marin and took over the criminal organizations there. Blüdhaven's protector Nightwing, and the all-knowing Oracle frequnently irritated the new Blockbuster. He took out his frustrations by snapping his underling's necks, creating the villain Torque when one victim inexplicably survived.

Desmond later developed albinism and his heart began to give out: side-effects of his gene bomb-derived powers. He received a heart tranplant from one of Gorilla City's talking apes, and was tightening his grip over Blüdhaven and contemplating a takeover of Gotham City when he was shot and killed by Tarantula.

Blockbuster was first seen in the Justice League Unlimited episode called "Kid's Stuff" where he, Cheetah, Copperhead and KGBeast were robbing a gold vault. Blockbuster is played by Dee Bradley Baker. Blockbuster is reported to be a member of the Legion of Doom shown on Justice League Unlimited.