Some of the Prominent Syro-Malabar Catholics in History are listed here (living personalities are not included):

• Parambil Chandy Malpan
• Archbishop Joseph Kariyattil
• Paremmakkal Thoma Kathanar
• Palackal Thoma Malpan
• Nidhiry Mani Kathanar
• Palakunnel Mathai Mariam Kathanar
• Mar Louis Pazheparambil
• Mar Augustine Kandathil - First Head of the Syro-Malabar Church
• Servant of God Mar Thomas Kurialachery
• St. Alphonsa of India
• Blessed Augustin Thevarparampil (Kunjachan)
• Blessed Evuprasia
• Mar Joseph Cardinal Parecattil
• Servant of God Mar Mathew Kavukatt
• Mar Antony Cardinal Padiyara
• Mar Abraham Kattumana

Blessed Chavara Achan

• Bishop Jonas Thaliath - Founder of Christ College, Bangalore
• Thachil Mathoo Tharakan - First non-Hindu minister of Travancore.
• C. J. Varkey - Minister of Madras Presidency.
• A.K. Antony- Current Defence Minister of India
• R. V. Thomas - President (Speaker) of Travancore Legislative Assembly (1948-50).
• Parambi Lonappan - Minister of Cochin State.
• P. T. Chacko - The only Christian Member of Indian Constituent Assembly from Kerala, and Home Minister of Kerala.
• A. J. John, Anaparambil - Chief Minister of Travancore-Cochin (1951-53) and Governor of Tamil Nadu.
• K. M. Geoge - Founder Member Kerala Congress and Minister in Kerala Govt.
• K. M. Chandy - Governor of Madhya Pradesh
• A. C. George - Minister in Government of India.
• Ezhupunna Parayil Avira Varkey Tharakan - Founder President of All Kerala Catholic Congress, the leading organization of Catholic laity.
• Elanjikkal Thariath Kunjithommen - Legislator who first espoused the cause of syrian catholic community (also, President, All Kerala Catholic Congress).
• Cyriac Kandathil - Organiser and General Secretary, All Kerala Catholic Congress, and Editor, Keraladeepam.

• Dr. P J Thomas - First Economic Advisor of Government of India.
• Anna Chandy - First woman judge of an Indian High Court.
• K.K. Mathew - First Christian Justice of the Supreme Court of India.
• Justice Thaliath - Chief Justice of Travancore State.
• Dr Jacob Thaliath - Surgeon General of Travancore State.
• Engineer P K Thresia - First Woman Chief Engineer of Kerala.
• Rev.Dr.Matthew Pothen Thekaekara- Eminent Spectroscopist associated with the Thekaekara Spectrum

• Paremmakkal Thoma Kathanar - Author of the first travelogue in an Indian language.
• Kuriakose Elias Chavara
• Nidhiry Mani Kathanar - Founder Editor of Deepika, the oldest Malayalam Daily.
• Mahakavi Kattakayam Cherian Mappillai - Poet and Editor of Literary Magazine
• I. C. Chacko, Illiparambil - Grammarian and one of the early recipients of the Sahitya Academy Award
• Mgr. Joseph C. Panjikaran
• Mgr. Jacob Naduvathussery
• Sr. Mary Benigna - Poet
• Mathew M. Kuzhively - The author of the first Encyclopedia in an Indian Language.
• Mahakavi P M Devasia - Poet
• Joseph Mundassery - Literary Critic and Social Reformer (later Education Minister of Kerala).
• M P Paul - Writer and Literary Critic
• K E Job - Church Historian, Educationlist and Text Book Writer
• V C George Church Historian

• Thachil Mathoo Tharakan - First timber exporter of South India
• Kunchacko - Founder of Udaya Studios, and pioneer of Malayalam Film industry.
• Joseph Augusti Kayalackakom - Founder of Palai Central Bank.
• Kulangara Paulo Hormis - Founder of Federal Bank.
• Joseph Murikken - Pioneer in large-scale paddy cultivation.
• Chakola Lonappan Palu - Leader in Textile Trade & Industry.
• Dominic Joseph Kuruvinakunnel - Founder of Casino (CGH Earth) Group of Hotels and Father of Tourism Industry in Kerala.
• Pothen Joseph Vadakekalom - Leading exporter of Spices.
• Dominic Chacko (DC) Kizhakkemuri - Foremost book publisher in Malayalam Language.

• P J Cherian - Artist and Drama Actor
• Joseph Kaimaparampan - Performer of Kathaprasangom (the art of musical story-telling).
• Miss Kumari - One of the early Actresses in Malayalam movies.
• Jimmy George - Outstanding International Volleyball Player.
• Fr. Abel - Founder of Kalabhavan.