Chattahoochee may refer to several places or things in the southeastern United States:

• Chattahoochee River, a river in Georgia, Alabama, and Florida
• Chattahoochee, Florida, a town in Gadsden County, Florida
• Chattahoochee, a metonym for the Florida State Hospital located in Chattahoochee, Florida
• Chattahoochee (film), a 1989 film starring Gary Oldman and Dennis Hopper set at the Florida State Hospital
• "Chattahoochee" (song), a song by Alan Jackson named for the Chattahoochee River
• "Chattahoochee" (38 Special song), a song by 38 Special on their Rock & Roll Strategy album named for the Florida State Hospital
• Chattahoochee County, Georgia, a county in the Columbus, Georgia, metropolitan area
• Chattahoochee Plantation, Georgia, a community in Cobb County, Georgia
• Chattahoochee High School, a high school in Alpharetta, Georgia
• Chattahoochee National Forest, part of the Chattahoochee-Oconee National Forest in northern Georgia