The Manhunters are a fictional 'race' of robot warriors that exists within the universe of DC Comics. They are humanoid in form and usually red and blue in color, although they are also masters of disguise.

The Manhunters were the first attempt of the Guardians of the Universe to create an interstellar police force that would combat evil all over the galaxy. Their name and much of their code of behaviour was modelled on that of the Martian Manhunters. For thousands of years, they served the Guardians well. However, the Manhunters became obsessed with the act of 'hunting' criminals. Their code, "No Man Escapes The Manhunters", became more important to them than seeing justice done.

Eventually, the robots conspired to rebel against their masters, but the Guardians defeated and destroyed most of them. Those that survived hid away on many planets, slowly rebuilding their forces and spreading their beliefs to others. Since then, the over-riding goal of the Manhunters has been to take revenge on the Guardians, as well as on their replacements, the Green Lantern Corps.

The Manhunters infiltrated many planets disguised as living beings and created a "Cult of the Manhunters" that trained others to be their minions. On Earth, most of the Manhunters' agents were unaware that their masters were robots, or that their real purposes were not noble. Some of these agents became superheroes also known as Manhunters. They wore red-and-blue costumes patterned after the Manhunters themselves. The most famous of these was a big game hunter called Paul Kirk. He was active in the 1940s, and starred in his own comic book. The character was brought back in a modern version in the 70s, in which he was supposedly killed years before but was in truth placed in suspended animation by a secret conspiracy. He was cloned, and when he finally reawoke, he dedicated himself to battle those who had used him, eventually dying in the process. However, some of his clones survived.

The Manhunters were discovered by the Justice League and seemingly defeated, and one of their human pawns, Mark Shaw, adopted a new identity as the costumed hero, The Privateer. However, he was later discovered to be a criminal posing as a hero.

Years later, it was revealed that the Manhunters not only still existed, but had infiltrated the lives of most superheroes with their agents. They revealed themselves when a Guardian and a member of the Zamarons tried to evolve some humans into becoming the next Guardians of the Universe, during what became known as the Millennium crisis. In this occasion, there was a massive counterstrike operation by the heroes against the Manhunters, and it seemed that they have finally been destroyed, along with their hidden home planet. Former Privateer Mark Shaw re-adopted his identity as Manhunter in the wake of the battle, seeking to redeem both the name and himself.

Since then, the Manhunters have reappeared several times, usually to bedevil Green Lantern or the JLA.

Manhunters has been shown in a Justice League Animated episode called "In the Blackest Night" and voiced by James Remar. The Manhunters bring Green Lantern John Stewart to trial for destroying the planet Adjuris 4. It is later revealed that the Manhunters betray the Oans with the help of Kanjar Ro.