Tissue therapy is a method initially proposed by Vladimir Filatov, that is based on a hypothesis of existing of biogenic stimulators (substances appearing in tissues exposed to unfavorable conditions) that stimulate inner powers of a treated organism.

A Soviet surgeon Vladimir Filatov treated corneal opacity by human cornea transplantation. At the first, transplantation material was taken from humans proceeded eye ectomy. Due to deficit of that material, Filatov tried to use corneas from died people, but that did not lead to satisfying results. During experimental work he revealed that corpses' corneas, saved at 3-4°C for several days, gave more positive results. Thus he made his practice in cornea transplantation massive.

As it seemed to Filatov in the time of engaging in that practice, the method also cured a number of diseases not connected to corneal opacity. He suggested that a piece of tissue placed in unfavorable conditions (cold and darkness) which still don't kill it, changes its metabolism for producing some yet unknown compounds, that serve saving it alive as long as possible. He named them biogenic stimulators.^[1]

Then he applied the same method to treating skin diseases, and (by 1933) he formulated^[2] main postulates of his doctrine of biogenic stimulators and tissue therapy.

After Filatov, the biogenic stimulators teaching mostly developed into obtaining of biogenic extracts from different materials of animal and plant origin, including placenta, vitreous body, aloe leaves and even peat. All biogenic extracts have common preparation technique: original material is exposed to specific cold temperatures for specific durations, then extraction is performed, the obtained extracts are packed in ampules and sterilized. These extracts are used subcutaneously as pharmaceutical and veterinary remedies in post-Soviet countries.^[3]