Sheen is a surname. Notable people with the surname include:

• Barry Sheen (1918–2005), British judge
• Bobby Sheen (1941–2000), American singer
• Caroline Sheen (born 1975), Welsh actress
• Daniel R. Sheen (1852-1926), American politician and lawyer
• Derek Sheen, American stand-up comedian
• Edna Sheen (1944–2012), American make-up artist
• Fulton J. Sheen (1895–1979), American Catholic archbishop, television evangelist, sainthood candidate
• Gillian Sheen (1928–2021), British fencer (won Olympic gold)
• Graham Sheen (born 1952), British bassoonist
• Grant Sheen (born 1974), English cricketer
• Jacqueline Sheen (born 1963), American model
• Janet Sheen (born 1944), American actress and producer
• Martin Sheen (originally Esteves, born 1940), American actor
  • Charlie Sheen (born 1965), American actor, son of Martin
• Michael Sheen (born 1969), Welsh actor
• Mickey Sheen (1927–1987), American jazz drummer
• Ruth Sheen (born 1952), English actress

Fictional characters:

• Emma Sheen, a character in the anime series Mobile Suit Zeta Gundam