Sergei Makarov or Sergey Makarov may refer to:

• Sergei Makarov (ice hockey, born 1958), Russian ice hockey right winger and two-time Olympic gold medalist
• Sergei Makarov (ice hockey, born 1964), Russian ice hockey defenceman
• Sergey Makarov (javelin thrower) (born 1973), Russian javelin thrower
• Sergey Makarov (volleyball), Russian volleyball player
• Sergei Makarov (footballer) (born 1996), Russian football midfielder