Sebastiano Santi (1788–1866) was an Italian painter, active both in oil and frescoes.

He was born in Murano and trained at the Academy of Fine Arts of Venice under Teodoro Matteini. His works are to be found in the Venetian churches. He painted the ceiling frescoes for the church of San Daniele, Padua.

• Bryan, Michael (1889). Walter Armstrong; Robert Edmund Graves (eds.). Dictionary of Painters and Engravers, Biographical and Critical. Vol. II: L-Z. London: George Bell and Sons. p. 449.