Sara Lee or Sarah Lee may refer to:

• Sarah Bowdich Lee (1791–1856), English writer and naturalist
• Sarah Lee (reporter) (born 1971), Korean American reporter for CNN
• Sarah Lee (golfer) (born 1979), South Korean professional golfer
• Sarah Tomerlin Lee, magazine editor and interior designer
• Sarah Lee (cyclist) (born 1987), Hong Kong professional racing cyclist
• Sara Lee (wrestler) (1992–2022), American professional wrestler
• Sara Lee (musician), English bassist and singer-songwriter
• Sarah Lee (actress), a Hong Kong–based actress, see School on Fire
• Sara Lee Corporation, an American consumer-goods company
• "Sarah Lee," a song by Foghat from their self-titled debut album