Santarelli is an Italian surname. Notable people with the surname include:

• Andrea Santarelli (born 1993), fencer

• Antonio Santarelli (archaeologist) (1832–1920), Italian archaeologist
• Antonio Santarelli (Jesuit) (1569–1649), Italian Jesuit
• Daniele Santarelli (born 1981), volleyball coach
• Emilio Santarelli, 19th-century Tuscan sculptor
• Giuseppe Santarelli (1710–1790), composer and singer
• Simone Santarelli, footballer