Santa Fe (Spanish; 'holy faith') or Santa Fé (Portuguese; 'holy faith') may refer to:

• Santa Fe, Argentina
  • Santa Fe Province

• Santa Fe de Yapacaní
• Santa Fe (Oruro)

• Bonito de Santa Fé
• Santa Fé de Goiás
• Santa Fé de Minas
• Santa Fé do Araguaia
• Santa Fé do Sul
• Santa Fé, Paraná

• Santa Fe (fort), near the island of Diego Diaz

• Santa Fe, Bogotá
• Santa Fe de Antioquia
• Santa Fe de Ralito

• Santa Fe, Havana
• Santa Fe, Isle of Youth

• Santa Fe Island, one of the Galápagos Islands

• Santa Fe, Colón
• Santa Fe, Ocotepeque

• Santa Fe, Mexico City
• Santa Fe de la Laguna

• Santa Fe, Darién
• Santa Fe District
• Santa Fe, Veraguas

• Santa Fe, Cebu
• Santa Fe, Leyte
• Santa Fe, Nueva Vizcaya
• Santa Fe, Romblon

• Santa Fe de Mondújar
• Santa Fe del Penedès
• Santa Fe, Granada

• New Mexico or Nuevo México, US state formerly Santa Fe de Nuevo México
  • Santa Fe de Nuevo México, a former province of New Spain and territory of Mexico (1598–1848)
  • Santa Fe, New Mexico, state capital
    • Santa Fe County, New Mexico
  • Santa Fe River (New Mexico)
• Rancho Santa Fe, California
• Santa Fe, Oakland, California
• Santa Fe Springs, California
• Lake Santa Fe, Alachua County, Florida
• Santa Fe River (Florida)
• Santa Fe Township, Clinton County, Illinois
• New Santa Fe, Indiana
• Santa Fe, Miami County, Indiana
• Santa Fe, Spencer County, Indiana
• Santa Fe, Missouri
• Santa Fe, Ohio
• Santa Fe, Oklahoma
• Santa Fe, Tennessee
• Santa Fe, Texas
• Terrenos Santa Fe, Texas

• Santa Fe (group), a musical trio
• "Santa Fe" (Bellamy Brothers song), a 1988 single by The Bellamy Brothers
• "Santa-Fe" (Bob Dylan song), a 1967 song by Bob Dylan
• "Santa Fe", a song from the 1990 Jon Bon Jovi album Blaze of Glory
• "Santa Fe", a song from the 2011 album The Rip Tide by Beirut
• "Santa Fe", a song from the musical Newsies
• "Santa Fe", a song from the musical Rent

• Santa Fe (film), a 1951 Western starring Randolph Scott
• Santa Fe (film), a 1997 drama starring Gary Cole
• Santa Fe (Kishin Shinoyama book), a 1991 photo book

• CD Santa Fe, a Spanish football club
• Colón de Santa Fe, an Argentine football club
• Independiente Santa Fe, a Colombian football club
• Unión de Santa Fe, an Argentine football club

• Hyundai Santa Fe, a sport utility vehicle

• ARA Santa Fe, the name of several ships of the Argentine navy
• SS Santa Fé (1921), a German cargo ship, sunk in the Black Sea in 1943
• SS Santa Fe (1943), a Liberian and Chilean Liberty ship, sunk in 1967
• USS Santa Fe, the name of two US Navy ships

• Atchison, Topeka and Santa Fe Railway, often known as just Santa Fe, US
• Chili Line, or Santa Fe Branch, US (1880s–1941)
• Santa Fe Southern Railway, New Mexico, US (1992–present)
• 2-10-2, the "Santa Fe" type wheel arrangement

• Gerónimo de Santa Fe (fl. 1400–1430), Spanish Christian convert, physician and writer
• Saint Faith, French 3rd century saint

• Disney's Hotel Santa Fe, a hotel at Disneyland Resort Paris
• Santa Fe Abbey, a former monastery in Zaragoza, Spain
• Santa Fe College, in Florida, U.S.
• Santa Fe Community College, in New Mexico, U.S.

• All pages with titles beginning with Santa Fe
• All pages with titles beginning with Santa Fé
• Sainte-Foy (disambiguation)
• Santa Fe High School (disambiguation)
• Santa Fe Depot (disambiguation)
• Santa Fe Station (disambiguation)
• Santa Fe Trail (disambiguation)
• Santa Fe Independent School District v. Doe, a U.S. Supreme Court case about school prayer