San Francisco District may refer to:

• Peru:
  • San Francisco District, Ambo
• Panama:
  • San Francisco District, Panama
• Costa Rica:
  • San Francisco District, Cartago (also known as Aguacaliente), in Cartago Canton, Cartago province
  • San Francisco District, Goicoechea, in Goicoechea Canton, San José province
  • San Francisco District, Heredia, in Heredia Canton, Heredia province
  • San Francisco District, San Isidro, in San Isidro Canton, Heredia province

• San Francisco (disambiguation)