Samuel Walker may refer to:

• Samuel Walker (gymnast) (1883–1960), British gymnast and Olympic medalist
• Samuel Walker (volleyball) (born 1995), Australian volleyball player
• Sammy Walker (ice hockey) (born 1999), American ice hockey player

• Samuel Walker (Massachusetts politician) (1793–1860), mayor of Roxbury, Massachusetts, 1851–1853
• Samuel Walker (1779–1851), English ironmaster, MP for Aldeburgh 1818–20
• Samuel Hamilton Walker (1817–1847), US Army major in the Mexican–American War and a Texas Rangers captain
• Samuel Walker (soldier) (1822–1893), American politician, and soldier
• Samuel Walker (Florida politician) (1825–1881), member of the Florida Legislature and mayor of Tallahassee
• Sir Samuel Walker, 1st Baronet (1832–1911), Irish politician and lawyer
• Samuel S. Walker (1841–1909), American businessman and politician in Michigan

• Samuel Walker of Truro (1714–1761), English evangelical clergyman
• J. Samuel Walker, American historian and author
• Samuel Dutton Walker (1833–1885), English architect
• Samuel Walker (police accountability expert) (born 1942), American police accountability expert

• Sam Walker (disambiguation)
• Sammy Walker (disambiguation)