Samuel Fisher may refer to:

• Samuel Fisher (Quaker) (1605–1665), English Quaker controversialist
• Samuel Fisher (died 1681) (c. 1605–1681), English ejected minister
• Samuel Fisher (clergyman) (1777–1857), American clergyman and educator
• Samuel Rhoads Fisher (1794–1839), secretary of the Navy of the Republic of Texas
• Samuel Rowland Fisher (1745–1834), Philadelphia merchant in Revolutionary times
• Samuel Fisher, Baron Fisher of Camden (1905–1979), British businessman and Jewish leader
• Samuel H. Fisher (1867–1957), American attorney and print historian

• Samuel von Fischer (1859–1934), Hungarian-born German publisher
• Sam Fisher (disambiguation)