Salpingitis
Micrograph of acute and chronic salpingitis. H&E stain.
Specialty	Gynecology

Salpingitis is an infection causing inflammation in the fallopian tubes (also called salpinges). It is often included in the umbrella term of pelvic inflammatory disease (PID), along with endometritis, oophoritis, myometritis, parametritis, and peritonitis.^[1][2]

The symptoms usually appear after a menstrual period. The most common are: an abnormal smell and colour of vaginal discharge, fever, nausea, vomiting, bloating, and frequent urination. Pain may be felt during ovulation, during periods, during sexual intercourse, on both sides of the abdomen, and lower back.^[3]

The infection usually has its origin in the vagina and ascends to the fallopian tube from there. Because the infection can spread via the lymph vessels, infection in one fallopian tube usually leads to infection of the other.^[3]

It's been theorized that retrograde menstrual flow and the cervix opening during menstruation allows the infection to reach the fallopian tubes.

Other risk factors include surgical procedures that break the cervical barrier, such as:

• endometrial biopsy
• curettage
• hysteroscopy^[2]

Another risk is factors that alter the microenvironment in the vagina and cervix, allowing infecting organisms to proliferate and eventually ascend to the fallopian tube:

• antibiotic treatment
• ovulation
• menstruation
• sexually transmitted infection (STI)

Finally, sexual intercourse may facilitate the spread of disease from the vagina to the fallopian tube. Coital risk factors are:

• Uterine contractions
• Sperm, carrying organisms upward

The bacteria most associated with salpingitis are:^[3]

• N. gonorrhoeae
• Chlamydia trachomatis
• Mycoplasma
• Staphylococcus
• Streptococcus

However, salpingitis is usually polymicrobial, involving many kinds of pathogens such as Ureaplasma urealyticum, and anaerobic and aerobic bacteria.

Salpingitis may be diagnosed by pelvic examination, blood tests, and/or a vaginal or cervical swab.

Salpingitis can be acute, chronic, or subclinical.^[4]

Approximately one in fourteen untreated Chlamydia infections will result in salpingitis.^[5]

Over one million cases of acute salpingitis are reported every year in the US, but the number of incidents is probably larger, due to incomplete and untimely reporting methods and that many cases are reported first when the illness has gone so far that it has developed chronic complications. For women age 16–25, salpingitis is the most common serious infection. It affects approximately 11% of females of reproductive age.^[2]

Salpingitis has a higher incidence among members of lower socioeconomic classes. However, this is thought of being an effect of earlier sexual debut, multiple partners, and decreased ability to receive proper health care rather than any independent risk factor for salpingitis.

As an effect of an increased risk due to multiple partners, the prevalence of salpingitis is highest for people age 15–24 years. Decreased awareness of symptoms and less will to use contraceptives are also common in this group, raising the occurrence of salpingitis.

For those affected, 20% need hospitalization. For those aged 15–44 years, 0.29 per 100,000 die from salpingitis.^[2]

One in six cases of salpingitis will lead to infertility.^[4] Salpingitis can also lead to tubal factor infertility because the eggs released in ovulation cannot make contact with the sperm. Approximately 75,000-225,000 cases of infertility in the US are caused by salpingitis. The more times one has the infection, the greater the risk of infertility. With one episode of salpingitis, the risk of infertility is 8-17%. With 3 episodes of salpingitis, the risk is 40-60%, although the exact risk depends on the severity of each episode.^[2]

Damaged oviducts from salpingitis increase the risk of an ectopic pregnancy by 7-10 fold. Half of ectopic pregnancies are due to a salpingitis infection.^[2]

Other complications are:^[3]

• Infection of ovaries and uterus
• Infection of sex partners
• An abscess on the ovary
• Internal scars resulting in Fitz-Hugh–Curtis syndrome of the liver^[6]

Salpingitis is most commonly caused by bacteria and typically treated with antibiotics.

E. coli, Gallibacterium and other bacteria can cause salpingitis in chickens and other poultry.^[7][8] This can result in lower egg production.^[8] Dairy cows can also have salpingitis.^[9]