Saint Sophia Church may refer to:

• Saint Sophia Church, Moscow, church in Moscow, Russia
• Saint Sophia Church (Nakhchivan-on-Don), church in Nakhchivan-on-Don, Rostov-on-Don city, Russia
• Church of Saint Sophia, Ohrid, church in Ohrid, North Macedonia
• Saint Sophia Church, Sofia, church in Sofia, Bulgaria
• St Sophia Greek Orthodox Church, Surry Hills, church in Surry Hills, New South Wales, Australia

• Sophia of Rome#Churches, for churches named after Saint Sophia of Rome
• Sofia Church (disambiguation)
• Hagia Sophia (disambiguation)
• Saint Sophia Cathedral (disambiguation)
• List of churches dedicated to Holy Wisdom