Human protein and coding gene
Syntaxin-7 is a protein that in humans is encoded by the STX7 gene .[ 5] [ 6]
In melanocytic cells STX7 gene expression may be regulated by MITF .[ 7]
Interactions STX7 has been shown to interact with STX8 ,[ 8] VPS18 ,[ 9] Vesicle-associated membrane protein 8 [ 8] [ 10] VPS11 .[ 9]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000079950 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019998 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Wang H, Frelin L, Pevsner J (October 1997). "Human syntaxin 7: a Pep12p/Vps6p homologue implicated in vesicle trafficking to lysosomes". Gene . 199 (1–2): 39–48. doi :10.1016/S0378-1119(97)00343-0 . PMID 9358037 . ^ "Entrez Gene: STX7 syntaxin 7" .^ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (December 2008). "Novel MITF targets identified using a two-step DNA microarray strategy" . Pigment Cell & Melanoma Research . 21 (6): 665–76. doi :10.1111/j.1755-148X.2008.00505.x PMID 19067971 . S2CID 24698373 . ^ a b Antonin W, Holroyd C, Fasshauer D, Pabst S, Von Mollard GF, Jahn R (December 2000). "A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function" . The EMBO Journal . 19 (23): 6453–64. doi :10.1093/emboj/19.23.6453 . PMC 305878 PMID 11101518 . ^ a b Kim BY, Krämer H, Yamamoto A, Kominami E, Kohsaka S, Akazawa C (August 2001). "Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7" . The Journal of Biological Chemistry . 276 (31): 29393–402. doi :10.1074/jbc.M101778200 PMID 11382755 . ^ Wade N, Bryant NJ, Connolly LM, Simpson RJ, Luzio JP, Piper RC, James DE (June 2001). "Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells" . The Journal of Biological Chemistry . 276 (23): 19820–7. doi :10.1074/jbc.M010838200 PMID 11278762 .
Further reading
Wong SH, Xu Y, Zhang T, Hong W (January 1998). "Syntaxin 7, a novel syntaxin member associated with the early endosomal compartment" . The Journal of Biological Chemistry . 273 (1): 375–80. doi :10.1074/jbc.273.1.375 PMID 9417091 . Steegmaier M, Yang B, Yoo JS, Huang B, Shen M, Yu S, Luo Y, Scheller RH (December 1998). "Three novel proteins of the syntaxin/SNAP-25 family" . The Journal of Biological Chemistry . 273 (51): 34171–9. doi :10.1074/jbc.273.51.34171 PMID 9852078 . Prekeris R, Yang B, Oorschot V, Klumperman J, Scheller RH (November 1999). "Differential roles of syntaxin 7 and syntaxin 8 in endosomal trafficking" . Molecular Biology of the Cell . 10 (11): 3891–908. doi :10.1091/mbc.10.11.3891 . PMC 25687 PMID 10564279 . Nakamura N, Yamamoto A, Wada Y, Futai M (March 2000). "Syntaxin 7 mediates endocytic trafficking to late endosomes" . The Journal of Biological Chemistry . 275 (9): 6523–9. doi :10.1074/jbc.275.9.6523 PMID 10692457 . Scales SJ, Chen YA, Yoo BY, Patel SM, Doung YC, Scheller RH (May 2000). "SNAREs contribute to the specificity of membrane fusion" . Neuron . 26 (2): 457–64. doi :10.1016/S0896-6273(00)81177-0 PMID 10839363 . Mullock BM, Smith CW, Ihrke G, Bright NA, Lindsay M, Parkinson EJ, Brooks DA, Parton RG, James DE, Luzio JP, Piper RC (September 2000). "Syntaxin 7 is localized to late endosome compartments, associates with Vamp 8, and Is required for late endosome-lysosome fusion" . Molecular Biology of the Cell . 11 (9): 3137–53. doi :10.1091/mbc.11.9.3137 . PMC 14981 PMID 10982406 . Antonin W, Holroyd C, Fasshauer D, Pabst S, Von Mollard GF, Jahn R (December 2000). "A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function" . The EMBO Journal . 19 (23): 6453–64. doi :10.1093/emboj/19.23.6453 . PMC 305878 PMID 11101518 . Wade N, Bryant NJ, Connolly LM, Simpson RJ, Luzio JP, Piper RC, James DE (June 2001). "Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells" . The Journal of Biological Chemistry . 276 (23): 19820–7. doi :10.1074/jbc.M010838200 PMID 11278762 . Kim BY, Krämer H, Yamamoto A, Kominami E, Kohsaka S, Akazawa C (August 2001). "Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7" . The Journal of Biological Chemistry . 276 (31): 29393–402. doi :10.1074/jbc.M101778200 PMID 11382755 . Rotem-Yehudar R, Galperin E, Horowitz M (August 2001). "Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29" . The Journal of Biological Chemistry . 276 (35): 33054–60. doi :10.1074/jbc.M009913200 PMID 11423532 . Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y (October 2001). "Protein-protein interaction panel using mouse full-length cDNAs" . Genome Research . 11 (10): 1758–65. doi :10.1101/gr.180101 . PMC 311163 PMID 11591653 . Antonin W, Fasshauer D, Becker S, Jahn R, Schneider TR (February 2002). "Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs". Nature Structural Biology . 9 (2): 107–11. doi :10.1038/nsb746 . hdl :11858/00-001M-0000-0012-F459-F PMID 11786915 . S2CID 17724790 . Antonin W, Dulubova I, Arac D, Pabst S, Plitzner J, Rizo J, Jahn R (September 2002). "The N-terminal domains of syntaxin 7 and vti1b form three-helix bundles that differ in their ability to regulate SNARE complex assembly" . The Journal of Biological Chemistry . 277 (39): 36449–56. doi :10.1074/jbc.M204369200 hdl :11858/00-001M-0000-0012-F2E6-3 PMID 12114520 . Bogdanovic A, Bennett N, Kieffer S, Louwagie M, Morio T, Garin J, Satre M, Bruckert F (November 2002). "Syntaxin 7, syntaxin 8, Vti1 and VAMP7 (vesicle-associated membrane protein 7) form an active SNARE complex for early macropinocytic compartment fusion in Dictyostelium discoideum" . The Biochemical Journal . 368 (Pt 1): 29–39. doi :10.1042/BJ20020845 . PMC 1222979 PMID 12175335 . Collins RF, Schreiber AD, Grinstein S, Trimble WS (September 2002). "Syntaxins 13 and 7 function at distinct steps during phagocytosis" . Journal of Immunology . 169 (6): 3250–6. doi :10.4049/jimmunol.169.6.3250 PMID 12218144 . Adkins JN, Varnum SM, Auberry KJ, Moore RJ, Angell NH, Smith RD, Springer DL, Pounds JG (December 2002). "Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry" . Molecular & Cellular Proteomics . 1 (12): 947–55. doi :10.1074/mcp.M200066-MCP200 PMID 12543931 . Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology . 21 (5): 566–9. doi :10.1038/nbt810 . PMID 12665801 . S2CID 23783563 . Suzuki J, Ohnishi H, Wada A, Hirayama T, Ohno H, Ueda N, Yasuda H, Iiri T, Wada Y, Futai M, Mashima H (July 2003). "Involvement of syntaxin 7 in human gastric epithelial cell vacuolation induced by the Helicobacter pylori-produced cytotoxin VacA" . The Journal of Biological Chemistry . 278 (28): 25585–90. doi :10.1074/jbc.M212445200 PMID 12730232 .
