Protein-coding gene in the species Homo sapiens
Small nuclear ribonucleoprotein Sm D3 is a protein that in humans is encoded by the SNRPD3 gene .[ 5] [ 6] [ 7]
Function The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis.[ 7]
Interactions SNRPD3 has been shown to interact with:
References
^ a b c GRCh38: Ensembl release 89: ENSG00000100028 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020180 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Lehmeier T, Foulaki K, Lührmann R (January 1991). "Evidence for three distinct D proteins, which react differentially with anti-Sm autoantibodies, in the cores of the major snRNPs U1, U2, U4/U6 and U5" . Nucleic Acids Res . 18 (22): 6475– 84. doi :10.1093/nar/18.22.6475 . PMC 332598 PMID 1701240 . ^ Lehmeier T, Raker V, Hermann H, Lührmann R (January 1995). "cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a direct D1-D2 interaction" . Proc Natl Acad Sci U S A . 91 (25): 12317– 21. Bibcode :1994PNAS...9112317L . doi :10.1073/pnas.91.25.12317 PMC 45428 PMID 7527560 . ^ a b "Entrez Gene: SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa" .^ Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (Dec 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry" . EMBO J . 19 (23): 6569– 81. doi :10.1093/emboj/19.23.6569 . PMC 305846 PMID 11101529 . ^ a b Friesen WJ, Paushkin S, Wyce A, Massenet S, Pesiridis GS, Van Duyne G, Rappsilber J , Mann M, Dreyfuss G (Dec 2001). "The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins" . Mol. Cell. Biol . 21 (24): 8289– 300. doi :10.1128/MCB.21.24.8289-8300.2001 . PMC 99994 PMID 11713266 . ^ Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (Dec 1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems" . J. Cell Biol . 147 (6): 1181– 94. doi :10.1083/jcb.147.6.1181 . PMC 2168095 PMID 10601333 .
Further reading
Liu Q, Fischer U, Wang F, Dreyfuss G (1997). "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins" . Cell . 90 (6): 1013– 21. doi :10.1016/S0092-8674(00)80367-0 PMID 9323129 . Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (1998). "Multiple protein: protein interactions between the snRNP common core proteins". Exp. Cell Res . 237 (1): 63– 9. doi :10.1006/excr.1997.3750 . PMID 9417867 . Kambach C, Walke S, Young R, Avis JM, de la Fortelle E, Raker VA, Lührmann R, Li J, Nagai K (1999). "Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs" . Cell . 96 (3): 375– 87. doi :10.1016/S0092-8674(00)80550-4 PMID 10025403 . Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (2000). "Gemin3: A Novel Dead Box Protein That Interacts with Smn, the Spinal Muscular Atrophy Gene Product, and Is a Component of Gems" . J. Cell Biol . 147 (6): 1181– 94. doi :10.1083/jcb.147.6.1181 . PMC 2168095 PMID 10601333 . Charroux B, Pellizzoni L, Perkinson RA, Yong J, Shevchenko A, Mann M, Dreyfuss G (2000). "Gemin4: A Novel Component of the Smn Complex That Is Found in Both Gems and Nucleoli" . J. Cell Biol . 148 (6): 1177– 86. doi :10.1083/jcb.148.6.1177 . PMC 2174312 PMID 10725331 . Brahms H, Raymackers J, Union A, de Keyser F, Meheus L, Lührmann R (2000). "The C-terminal RG dipeptide repeats of the spliceosomal Sm proteins D1 and D3 contain symmetrical dimethylarginines, which form a major B-cell epitope for anti-Sm autoantibodies" . J. Biol. Chem . 275 (22): 17122– 9. doi :10.1074/jbc.M000300200 hdl :11858/00-001M-0000-0012-F7F0-E PMID 10747894 . Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (2001). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry" . EMBO J . 19 (23): 6569– 81. doi :10.1093/emboj/19.23.6569 . PMC 305846 PMID 11101529 . Urlaub H, Raker VA, Kostka S, Lührmann R (2001). "Sm protein–Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure" . EMBO J . 20 (1– 2): 187– 96. doi :10.1093/emboj/20.1.187 . PMC 140196 PMID 11226169 . Friesen WJ, Massenet S, Paushkin S, Wyce A, Dreyfuss G (2001). "SMN, the product of the spinal muscular atrophy gene, binds preferentially to dimethylarginine-containing protein targets" . Mol. Cell . 7 (5): 1111– 7. doi :10.1016/S1097-2765(01)00244-1 PMID 11389857 . Friesen WJ, Paushkin S, Wyce A, Massenet S, Pesiridis GS, Van Duyne G, Rappsilber J, Mann M, Dreyfuss G (2001). "The Methylosome, a 20S Complex Containing JBP1 and pICln, Produces Dimethylarginine-Modified Sm Proteins" . Mol. Cell. Biol . 21 (24): 8289– 300. doi :10.1128/MCB.21.24.8289-8300.2001 . PMC 99994 PMID 11713266 . Gubitz AK, Mourelatos Z, Abel L, Rappsilber J, Mann M, Dreyfuss G (2002). "Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins" . J. Biol. Chem . 277 (7): 5631– 6. doi :10.1074/jbc.M109448200 PMID 11714716 . Meister G, Eggert C, Bühler D, Brahms H, Kambach C, Fischer U (2002). "Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln". Curr. Biol . 11 (24): 1990– 4. doi :10.1016/S0960-9822(01)00592-9 . hdl :11858/00-001M-0000-0012-F501-7 PMID 11747828 . S2CID 14742376 . Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G (2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component" . J. Biol. Chem . 277 (9): 7540– 5. doi :10.1074/jbc.M110141200 PMID 11748230 . Friesen WJ, Wyce A, Paushkin S, Abel L, Rappsilber J, Mann M, Dreyfuss G (2002). "A novel WD repeat protein component of the methylosome binds Sm proteins" . J. Biol. Chem . 277 (10): 8243– 7. doi :10.1074/jbc.M109984200 PMID 11756452 . Fong YW, Zhou Q (2002). "Stimulatory effect of splicing factors on transcriptional elongation". Nature . 414 (6866): 929– 33. doi :10.1038/414929a . PMID 11780068 . S2CID 1518837 . Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (2002). "Directed proteomic analysis of the human nucleolus" . Curr. Biol . 12 (1): 1– 11. doi :10.1016/S0960-9822(01)00650-9 PMID 11790298 . Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis" . RNA . 8 (4): 426– 39. doi :10.1017/S1355838202021088 . PMC 1370266 PMID 11991638 . Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex" . J. Biol. Chem . 277 (35): 31957– 62. doi :10.1074/jbc.M203478200 PMID 12065586 .
