Langbahn Team – Weltmeisterschaft

SND1

SND1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSND1, TDRD11, p100, staphylococcal nuclease and tudor domain containing 1, Tudor-SN
External IDsOMIM: 602181; MGI: 1929266; HomoloGene: 8665; GeneCards: SND1; OMA:SND1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

27044

56463

Ensembl

ENSG00000197157

ENSMUSG00000001424

UniProt

Q7KZF4

Q78PY7

RefSeq (mRNA)

NM_014390

NM_019776

RefSeq (protein)

NP_055205

NP_062750

Location (UCSC)Chr 7: 127.65 – 128.09 MbChr 6: 28.48 – 28.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Staphylococcal nuclease domain-containing protein 1 also known as 100 kDa coactivator or Tudor domain-containing protein 11 (TDRD11) is a protein that in humans is encoded by the SND1 gene.[5][6][7][8] SND1 is a main component of RISC complex[9] and plays an important role in miRNA function.[10][11] SND1 is Tudor domain containing protein and Tudor Proteins are highly conserved proteins and even present in Drosophila melanogaster.[12] SND1 is also involved in Autism.[13]

Clinical significance

SND1 acts as oncogene in many cancers[14][15][16] and in hepatocellular carcinoma progression.[10][11] SND1 promotes tumor angiogenesis in human hepatocellular carcinoma through a novel pathway which involves NF-kappaB and miR-221.[17] SND1 promotes migration and invasion via angiotensin II type 1 receptor and TGFβ signaling.[18] SND1 expression is regulated by Mir-184 in gliomas.[19]

Interactions

SND1 has been shown to interact with MYB,[20]

SND1 also interacts with G3BP (stress granule protein)[25] and AEG-1.[10][11]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000197157 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001424 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tong X, Drapkin R, Yalamanchili R, Mosialos G, Kieff E (Sep 1995). "The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE". Molecular and Cellular Biology. 15 (9): 4735–44. doi:10.1128/mcb.15.9.4735. PMC 230717. PMID 7651391.
  6. ^ Callebaut I, Mornon JP (Jan 1997). "The human EBNA-2 coactivator p100: multidomain organization and relationship to the staphylococcal nuclease fold and to the tudor protein involved in Drosophila melanogaster development". The Biochemical Journal. 321 (1): 125–32. doi:10.1042/bj3210125. PMC 1218045. PMID 9003410.
  7. ^ Paukku K, Yang J, Silvennoinen O (Sep 2003). "Tudor and nuclease-like domains containing protein p100 function as coactivators for signal transducer and activator of transcription 5". Molecular Endocrinology. 17 (9): 1805–14. doi:10.1210/me.2002-0256. PMID 12819296.
  8. ^ "Entrez Gene: SND1 staphylococcal nuclease and tudor domain containing 1".
  9. ^ Tsuchiya N, Ochiai M, Nakashima K, Ubagai T, Sugimura T, Nakagama H (Oct 2007). "SND1, a component of RNA-induced silencing complex, is up-regulated in human colon cancers and implicated in early stage colon carcinogenesis". Cancer Research. 67 (19): 9568–76. doi:10.1158/0008-5472.CAN-06-2707. PMID 17909068.
  10. ^ a b c Yoo BK, Santhekadur PK, Gredler R, Chen D, Emdad L, Bhutia S, Pannell L, Fisher PB, Sarkar D (May 2011). "Increased RNA-induced silencing complex (RISC) activity contributes to hepatocellular carcinoma". Hepatology. 53 (5): 1538–48. doi:10.1002/hep.24216. PMC 3081619. PMID 21520169.
  11. ^ a b c Yoo BK, Emdad L, Lee SG, Su ZZ, Santhekadur P, Chen D, Gredler R, Fisher PB, Sarkar D (Apr 2011). "Astrocyte elevated gene-1 (AEG-1): A multifunctional regulator of normal and abnormal physiology". Pharmacology & Therapeutics. 130 (1): 1–8. doi:10.1016/j.pharmthera.2011.01.008. PMC 3043119. PMID 21256156.
  12. ^ Ying, Muying; Chen, Dahua (1 January 2012). "Tudor domain-containing proteins of Drosophila melanogaster". Development, Growth & Differentiation. 54 (1): 32–43. doi:10.1111/j.1440-169X.2011.01308.x. PMID 23741747. S2CID 23227910.
  13. ^ Holt R, Barnby G, Maestrini E, Bacchelli E, Brocklebank D, Sousa I, Mulder EJ, Kantojärvi K, Järvelä I, Klauck SM, Poustka F, Bailey AJ, Monaco AP (Sep 2010). "Linkage and candidate gene studies of autism spectrum disorders in European populations". European Journal of Human Genetics. 18 (9): 1013–9. doi:10.1038/ejhg.2010.69. PMC 2987412. PMID 20442744.
  14. ^ Tsuchiya N, Nakagama H (Nov 2010). "MicroRNA, SND1, and alterations in translational regulation in colon carcinogenesis". Mutation Research. 693 (1–2): 94–100. doi:10.1016/j.mrfmmm.2010.09.001. PMID 20883704.
  15. ^ Kuruma H, Kamata Y, Takahashi H, Igarashi K, Kimura T, Miki K, Miki J, Sasaki H, Hayashi N, Egawa S (Jun 2009). "Staphylococcal nuclease domain-containing protein 1 as a potential tissue marker for prostate cancer". The American Journal of Pathology. 174 (6): 2044–50. doi:10.2353/ajpath.2009.080776. PMC 2684170. PMID 19435788.
  16. ^ Ho J, Kong JW, Choong LY, Loh MC, Toy W, Chong PK, Wong CH, Wong CY, Shah N, Lim YP (Feb 2009). "Novel breast cancer metastasis-associated proteins". Journal of Proteome Research. 8 (2): 583–94. doi:10.1021/pr8007368. PMID 19086899.
  17. ^ Santhekadur PK, Das SK, Gredler R, Chen D, Srivastava J, Robertson C, Baldwin AS, Fisher PB, Sarkar D (Apr 2012). "Multifunction protein staphylococcal nuclease domain containing 1 (SND1) promotes tumor angiogenesis in human hepatocellular carcinoma through novel pathway that involves nuclear factor κB and miR-221". The Journal of Biological Chemistry. 287 (17): 13952–8. doi:10.1074/jbc.M111.321646. PMC 3340184. PMID 22396537.
  18. ^ Santhekadur PK, Akiel M, Emdad L, Gredler R, Srivastava J, Rajasekaran D, Robertson CL, Mukhopadhyay ND, Fisher PB, Sarkar D (2014). "Staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGFβ signaling". FEBS Open Bio. 4: 353–61. doi:10.1016/j.fob.2014.03.012. PMC 4050181. PMID 24918049.
  19. ^ Emdad L, Janjic A, Alzubi MA, Hu B, Santhekadur PK, Menezes ME, Shen XN, Das SK, Sarkar D, Fisher PB (Mar 2015). "Suppression of miR-184 in malignant gliomas upregulates SND1 and promotes tumor aggressiveness". Neuro-Oncology. 17 (3): 419–29. doi:10.1093/neuonc/nou220. PMC 4483100. PMID 25216670.
  20. ^ Dash AB, Orrico FC, Ness SA (Aug 1996). "The EVES motif mediates both intermolecular and intramolecular regulation of c-Myb". Genes & Development. 10 (15): 1858–69. doi:10.1101/gad.10.15.1858. PMID 8756344.
  21. ^ Leverson JD, Koskinen PJ, Orrico FC, Rainio EM, Jalkanen KJ, Dash AB, Eisenman RN, Ness SA (Oct 1998). "Pim-1 kinase and p100 cooperate to enhance c-Myb activity". Molecular Cell. 2 (4): 417–25. doi:10.1016/S1097-2765(00)80141-0. PMID 9809063.
  22. ^ a b Yang J, Aittomäki S, Pesu M, Carter K, Saarinen J, Kalkkinen N, Kieff E, Silvennoinen O (Sep 2002). "Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II". The EMBO Journal. 21 (18): 4950–8. doi:10.1093/emboj/cdf463. PMC 126276. PMID 12234934.
  23. ^ Zhou S, Fujimuro M, Hsieh JJ, Chen L, Hayward SD (Feb 2000). "A role for SKIP in EBNA2 activation of CBF1-repressed promoters". Journal of Virology. 74 (4): 1939–47. doi:10.1128/jvi.74.4.1939-1947.2000. PMC 111672. PMID 10644367.
  24. ^ Hsieh JJ, Zhou S, Chen L, Young DB, Hayward SD (Jan 1999). "CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex". Proceedings of the National Academy of Sciences of the United States of America. 96 (1): 23–8. Bibcode:1999PNAS...96...23H. doi:10.1073/pnas.96.1.23. PMC 15086. PMID 9874765.
  25. ^ Gao X, Ge L, Shao J, Su C, Zhao H, Saarikettu J, Yao X, Yao Z, Silvennoinen O, Yang J (Aug 2010). "Tudor-SN interacts with and co-localizes with G3BP in stress granules under stress conditions". FEBS Letters. 584 (16): 3525–32. doi:10.1016/j.febslet.2010.07.022. PMC 7127458. PMID 20643132.

Further reading

Quelle: https://en.wikipedia.org/wiki/SND1