Protein-coding gene in the species Homo sapiens
E3 ubiquitin-protein ligase SHPRH is an enzyme that in humans is encoded by the SHPRH gene .[ 5] [ 6]
Function SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases.[supplied by OMIM][ 6] [ 7]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000146414 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000090112 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Sood R, Makalowska I, Galdzicki M, Hu P, Eddings E, Robbins CM, Moses T, Namkoong J, Chen S, Trent JM (August 2003). "Cloning and characterization of a novel gene, SHPRH, encoding a conserved putative protein with SNF2/helicase and PHD-finger domains from the 6q24 region" . Genomics . 82 (2): 153–61. doi :10.1016/S0888-7543(03)00121-6 . PMID 12837266 . ^ a b "Entrez Gene: SHPRH SNF2 histone linker PHD RING helicase" .^ Brühl, J; Trautwein, J; Schäfer, A; Linne, U; Bouazoune, K (21 August 2019). "The DNA repair protein SHPRH is a nucleosome-stimulated ATPase and a nucleosome-E3 ubiquitin ligase" . Epigenetics & Chromatin . 12 (1): 52. doi :10.1186/s13072-019-0294-5 PMC 6702750 PMID 31434570 .
Further reading
Motegi A, Sood R, Moinova H, Markowitz SD, Liu PP, Myung K (December 2006). "Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination" . The Journal of Cell Biology . 175 (5): 703–8. doi :10.1083/jcb.200606145 . PMC 2064669 PMID 17130289 . Unk I, Hajdú I, Fátyol K, Szakál B, Blastyák A, Bermudez V, Hurwitz J, Prakash L, Prakash S, Haracska L (November 2006). "Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen" . Proceedings of the National Academy of Sciences of the United States of America . 103 (48): 18107–12. Bibcode :2006PNAS..10318107U . doi :10.1073/pnas.0608595103 PMC 1838714 PMID 17108083 . Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (August 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization" (PDF) . Current Biology . 14 (16): 1436–50. doi :10.1016/j.cub.2004.07.051 . PMID 15324660 . S2CID 2371325 . Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (September 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF) . Nature . 377 (6547 Suppl): 3–174. PMID 7566098 .
