Protein-coding gene in the species Homo sapiens
Sodium channel β-subunit 4 , also known as SCN4B or Naβ4, is an auxiliary sodium channel subunit that can alter the kinetics of sodium channels.[ 5] protein is encoded by the SCN4B gene .[ 6] SCN4B are associated with long QT syndrome .[ 7]
SCN4B might additionally function as a cell adhesion molecule.[ 8] [ 9]
See also
References
^ a b c GRCh38: Ensembl release 89: ENSG00000177098 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000046480 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Lewis, Amanda H.; Raman, Indira M. (2014-11-15). "Resurgent current of voltage-gated Na+ channels" . The Journal of Physiology . 592 (22): 4825–4838. doi :10.1113/jphysiol.2014.277582 . ISSN 1469-7793 . PMC 4259529 PMID 25172941 . ^ "Entrez Gene: sodium channel" .^ Medeiros-Domingo A, Kaku T, Tester DJ, Iturralde-Torres P, Itty A, Ye B, Valdivia C, Ueda K, Canizales-Quinteros S, Tusié-Luna MT, Makielski JC, Ackerman MJ (July 2007). "SCN4B-encoded sodium channel beta4 subunit in congenital long-QT syndrome" . Circulation . 116 (2): 134–42. doi :10.1161/CIRCULATIONAHA.106.659086 . PMC 3332546 PMID 17592081 . ^ Shimizu, Hideaki (2016). "Structure-based site-directed photo-crosslinking analyses of multimeric cell-adhesive interactions of voltage-gated sodium channel β subunits" . Scientific Reports . 6 : 26618. Bibcode :2016NatSR...626618S . doi :10.1038/srep26618 . PMC 4877568 PMID 27216889 . ^ Shimizu, Hideaki (2017). "Parallel homodimer structures of the extracellular domains of the voltage-gated sodium channel β4 subunit explain its role in cell-cell adhesion" . J Biol Chem . 27 (32): 13428–13440. doi :10.1074/jbc.M117.786509 PMC 5555201 PMID 28655765 .
Delgado P, GarcÃa-Zueco JC, Rubio-Félix D, Giralt M (1992). "[Idiopathic thrombocytopenic purpura: present knowledge and future expectations]". Sangre . 37 (6): 449–56. PMID 1293796 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Yu FH, Westenbroek RE, Silos-Santiago I, et al. (2003). "Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2" . J. Neurosci . 23 (20): 7577–85. doi :10.1523/JNEUROSCI.23-20-07577.2003 PMC 6740763 PMID 12930796 . Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55–65. doi :10.1101/gr.4039406 . PMC 1356129 PMID 16344560 . Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Webb J, Wu FF, Cannon SC (2009). "Slow inactivation of the NaV1.4 sodium channel in mammalian cells is impeded by co-expression of the beta1 subunit" . Pflügers Arch . 457 (6): 1253–63. doi :10.1007/s00424-008-0600-8 . PMC 6207185 PMID 18941776 . Shimizu, Hideaki (2016). "Structure-based site-directed photo-crosslinking analyses of multimeric cell-adhesive interactions of voltage-gated sodium channel β subunits" . Scientific Reports . 6 : 26618. Bibcode :2016NatSR...626618S . doi :10.1038/srep26618 . PMC 4877568 PMID 27216889 .
External links Overview of all the structural information available in the PDB for UniProt : Q8IWT1 PDBe-KB . 
