Rufinus may refer to:

• Saints Rufinus, eleven saints named Rufinus in Roman Martyrology, including:
  • Rufinus of Assisi, 3rd-century saint and martyr
  • Valerius and Rufinus (d. 287), Christian martyrs
• Rufinus (Roman governor), 3rd century governor of Roman Britain
• Rufinus (consul) (c. 335–395), Eastern Roman statesman
• Tyrannius Rufinus of Aquileia (c. 340–410), Roman monk, historian, and translator
• Rufinus (relative of Theodosius II), 5th century
• Rufinus (poet) of the Greek Anthology
• Rufinus (decretist), 12th-century canon lawyer
• Rufinus Widl (1731–1798), Benedictine monk
• Rufinus (Byzantine official) 5th/6th-centuries Byzantine military officer and emissary

• Rufino (disambiguation)