RhoD (Ras homolog gene family, member D) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases.[5] It is encoded by the gene RHOD.[6]
It binds GTP and is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton.[6][7]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Ridley AJ (October 2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking". Trends in Cell Biology. 16 (10): 522–529. doi:10.1016/j.tcb.2006.08.006. PMID16949823.
Shimizu F, Watanabe TK, Okuno S, Omori Y, Fujiwara T, Takahashi E, Nakamura Y (March 1997). "Isolation of a novel human cDNA (rhoHP1) homologous to rho genes". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1351 (1–2): 13–16. doi:10.1016/s0167-4781(97)00008-0. PMID9116026.
Kim HS, Choi JY, Jung AR, Jang KL, Lee WH, Choi WC, et al. (2000). "Assignment of the human RhoHP1 gene (ARHD) to chromosome 11q14.3 by radiation hybrid mapping". Cytogenetics and Cell Genetics. 89 (1–2): 53. doi:10.1159/000015562. PMID10894936. S2CID84584317.
Murphy C, Saffrich R, Olivo-Marin JC, Giner A, Ansorge W, Fotsis T, Zerial M (June 2001). "Dual function of rhoD in vesicular movement and cell motility". European Journal of Cell Biology. 80 (6): 391–398. doi:10.1078/0171-9335-00173. PMID11484930.
Ito Y, Kanamaru A, Tada A (March 2007). "A novel agent, methylophiopogonanone B, promotes Rho activation and tubulin depolymerization". Molecular and Cellular Biochemistry. 297 (1–2): 121–129. doi:10.1007/s11010-006-9336-y. PMID17029007. S2CID33688226.
Lakshman N, Kim A, Bayless KJ, Davis GE, Petroll WM (June 2007). "Rho plays a central role in regulating local cell-matrix mechanical interactions in 3D culture". Cell Motility and the Cytoskeleton. 64 (6): 434–445. doi:10.1002/cm.20194. PMID17342762.
PDB gallery
2j1l: CRYSTAL STRUCTURE OF HUMAN RHO-RELATED GTP-BINDING PROTEIN RHOD