Rhein-Mosel is a Verbandsgemeinde ("collective municipality") in the district Mayen-Koblenz, in Rhineland-Palatinate, Germany. It is situated along the lower course of the river Moselle, south-west of Koblenz. The seat of the municipality is in Kobern-Gondorf. It was formed on 1 July 2014 by the merger of the former Verbandsgemeinden Untermosel and Rhens.

The Verbandsgemeinde Rhein-Mosel consists of the following Ortsgemeinden ("local municipalities"):

50°18′N 7°27′E / 50.300°N 7.450°E / 50.300; 7.450