Langbahn Team – Weltmeisterschaft

60S ribosomal protein L7

RPL7
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRPL7, L7, humL7-1, ribosomal protein L7, ribosomal protein uL30
External IDsOMIM: 604166; MGI: 98073; HomoloGene: 87772; GeneCards: RPL7; OMA:RPL7 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000971
NM_001363737

NM_011291

RefSeq (protein)

NP_000962
NP_001350666

NP_035421

Location (UCSC)Chr 8: 73.29 – 73.3 MbChr 1: 16.17 – 16.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

60S ribosomal protein L7 is a protein that in humans is encoded by the RPL7 gene.[5][6][7]

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30P family of ribosomal proteins. It contains an N-terminal basic region-leucine zipper (BZIP)-like domain and the RNP consensus sub-motif RNP2. In vitro the BZIP-like domain mediates homodimerization and stable binding to DNA and RNA, with a preference for 28S rRNA and mRNA. The protein can inhibit cell-free translation of mRNAs, suggesting that it plays a regulatory role in the translation apparatus. It is located in the cytoplasm. The protein has been shown to be an autoantigen in patients with systemic autoimmune diseases, such as systemic lupus erythematosus. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[7]

Interactions

RPL7 has been shown to interact with ZNF7.[8] It interacts with HIV-1 Gag protein through Zinc Finger of HIV-1 Gag.[9]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000147604Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043716Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Seshadri T, Uzman JA, Oshima J, Campisi J (September 1993). "Identification of a transcript that is down-regulated in senescent human fibroblasts. Cloning, sequence analysis, and regulation of the human L7 ribosomal protein gene". The Journal of Biological Chemistry. 268 (25): 18474–80. doi:10.1016/S0021-9258(17)46650-6. PMID 8360149.
  6. ^ Hemmerich P, von Mikecz A, Neumann F, Sözeri O, Wolff-Vorbeck G, Zoebelein R, Krawinkel U (January 1993). "Structural and functional properties of ribosomal protein L7 from humans and rodents". Nucleic Acids Research. 21 (2): 223–31. doi:10.1093/nar/21.2.223. PMC 309096. PMID 8441630.
  7. ^ a b "Entrez Gene: RPL7 ribosomal protein L7".
  8. ^ Witte S, Krawinkel U (August 1997). "Specific interactions of the autoantigen L7 with multi-zinc finger protein ZNF7 and ribosomal protein S7". The Journal of Biological Chemistry. 272 (35): 22243–7. doi:10.1074/jbc.272.35.22243. PMID 9268371.
  9. ^ Mekdad HE, Boutant E, Karnib H, Biedma ME, Sharma KK, Malytska I, et al. (August 2016). "Characterization of the interaction between the HIV-1 Gag structural polyprotein and the cellular ribosomal protein L7 and its implication in viral nucleic acid remodeling". Retrovirology. 13 (1): 54. doi:10.1186/s12977-016-0287-4. PMC 4982112. PMID 27515235.

Further reading