Roe or hard roe, is the fully ripe egg masses of fish and certain marine invertebrates.

Roe or ROE may also refer to:

• Electoral district of Roe, Western Australia
• Roe Botanical District or Mallee, a biogeographic region in southern Western Australia
• Roe Plains, Western Australia, a coastal plain
• Roe River (Western Australia)

• Roe Beck, Cumbria, England, also known as the River Roe in its lower reaches
• River Roe, County Londonderry, Northern Ireland

• Roe, Arkansas, a town
• Roe River, Montana
• Roes Spring, a stream in Georgia

• Roe (surname)
• Roe (given name)

• Ring of Elysium (RoE), a 2018 battle royale video game developed by Tencent Games
• Rise of the Eldrazi (ROE), a Magic: The Gathering expansion
• Rubies of Eventide (ROE), a defunct massively multiplayer online role-playing game

• USS Roe (DD-24), a modified Paulding-class destroyer launched in 1909
• USS Roe (DD-418), a Sims-class destroyer launched in 1939

• Roe (ship), two slave ships
• Roe Highway, a highway in the suburbs of Perth, Western Australia
• Rosedale railway station, Australia
• Rotherhithe railway station, London, National Rail station code

• Roe deer
• Roe v. Wade, a landmark 1973 United States Supreme Court decision on the issue of abortion
  • Norma McCorvey, plaintiff known pseudonymously as "Jane Roe"
• Return on equity or ROE, the rate of return for ownership interest of common stock owners
• Royal Observatory, Edinburgh or ROE, Scotland, UK
• Rules of engagement, the internal rules or directives among military forces
• Charles H. Roe, a British coachbuilding company
• "Roe", a season 5 episode of Boston Legal

• Pseudonyms for parties whose true identity is unknown or must be withheld in a legal matter:
  • Jane Roe (pseudonym)
  • Richard Roe (pseudonym)
• Roes, a townland in Inver, County Donegal, Ireland
• Row (disambiguation)
• Rowe (disambiguation)