Protein-coding gene in the species Homo sapiens
This article is about the human gene. For the hand gesture, see
Rabia sign .
Ras-related protein Rab-3A is a protein that in humans is encoded by the RAB3A gene .[ 5] [ 6] [ 7]
Interactions RAB3A has been shown to interact with:
References
^ a b c GRCh38: Ensembl release 89: ENSG00000105649 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031840 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Rousseau-Merck MF, Zahraoui A, Bernheim A, Touchot N, Miglierina R, Tavitian A, Berger R (January 1990). "Chromosome mapping of the human ras-related rab3A gene to 19p13.2". Genomics . 5 (4): 694–8. doi :10.1016/0888-7543(89)90110-9 . PMID 2687157 . ^ Brondyk WH, McKiernan CJ, Fortner KA, Stabila P, Holz RW, Macara IG (March 1995). "Interaction cloning of Rabin3, a novel protein that associates with the Ras-like GTPase Rab3A" . Mol Cell Biol . 15 (3): 1137–43. doi :10.1128/MCB.15.3.1137 . PMC 230335 PMID 7532276 . ^ "Entrez Gene: RAB3A RAB3A, member RAS oncogene family" .^ a b Fukuda M (April 2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2" . J. Biol. Chem . 278 (17): 15373–80. doi :10.1074/jbc.M212341200 PMID 12578829 . ^ Betz A, Thakur P, Junge HJ, Ashery U, Rhee JS, Scheuss V, Rosenmund C, Rettig J, Brose N (April 2001). "Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming". Neuron . 30 (1): 183–96. doi :10.1016/s0896-6273(01)00272-0 . hdl :11858/00-001M-0000-0012-F596-C PMID 11343654 . S2CID 155875 . ^ "Protein unc-13 homolog A" . UniProt .^ Ostermeier C, Brunger AT (February 1999). "Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A" . Cell . 96 (3): 363–74. doi :10.1016/S0092-8674(00)80549-8 PMID 10025402 . S2CID 15162326 . ^ Weber E, Jilling T, Kirk KL (March 1996). "Distinct functional properties of Rab3A and Rab3B in PC12 neuroendocrine cells" . J. Biol. Chem . 271 (12): 6963–71. doi :10.1074/jbc.271.12.6963 PMID 8636125 . ^ Cremers FP, Armstrong SA, Seabra MC, Brown MS, Goldstein JL (January 1994). "REP-2, a Rab escort protein encoded by the choroideremia-like gene" . J. Biol. Chem . 269 (3): 2111–7. doi :10.1016/S0021-9258(17)42142-9 PMID 8294464 . ^ Pereira-Leal JB, Strom M, Godfrey RF, Seabra MC (January 2003). "Structural determinants of Rab and Rab Escort Protein interaction: Rab family motifs define a conserved binding surface". Biochem. Biophys. Res. Commun . 301 (1): 92–7. doi :10.1016/s0006-291x(02)02963-7 . PMID 12535645 .
Further reading
Khosravi-Far R, Lutz RJ, Cox AD, Conroy L, Bourne JR, Sinensky M, Balch WE, Buss JE, Der CJ (1991). "Isoprenoid modification of rab proteins terminating in CC or CXC motifs" . Proc. Natl. Acad. Sci. U.S.A . 88 (14): 6264–8. Bibcode :1991PNAS...88.6264K . doi :10.1073/pnas.88.14.6264 PMC 52063 PMID 1648736 . Zahraoui A, Touchot N, Chardin P, Tavitian A (1989). "The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion" . J. Biol. Chem . 264 (21): 12394–401. doi :10.1016/S0021-9258(18)63872-4 PMID 2501306 . Farnsworth CC, Seabra MC, Ericsson LH, Gelb MH, Glomset JA (1995). "Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A" . Proc. Natl. Acad. Sci. U.S.A . 91 (25): 11963–7. Bibcode :1994PNAS...9111963F . doi :10.1073/pnas.91.25.11963 PMC 45356 PMID 7991565 . McKiernan CJ, Brondyk WH, Macara IG (1993). "The Rab3A GTPase interacts with multiple factors through the same effector domain. Mutational analysis of cross-linking of Rab3A to a putative target protein" . J. Biol. Chem . 268 (32): 24449–52. doi :10.1016/S0021-9258(20)80546-8 PMID 8226995 . Trask B, Fertitta A, Christensen M, Youngblom J, Bergmann A, Copeland A, de Jong P, Mohrenweiser H, Olsen A, Carrano A (1993). "Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers" . Genomics . 15 (1): 133–45. doi :10.1006/geno.1993.1021 . PMID 8432525 . Johannes L, Perez F, Laran-Chich MP, Henry JP, Darchen F (1996). "Characterization of the interaction of the monomeric GTP-binding protein Rab3a with geranylgeranyl transferase II". Eur. J. Biochem . 239 (2): 362–8. doi :10.1111/j.1432-1033.1996.0362u.x . PMID 8706741 . Burton JL, Slepnev V, De Camilli PV (1997). "An evolutionarily conserved domain in a subfamily of Rabs is crucial for the interaction with the guanyl nucleotide exchange factor Mss4" . J. Biol. Chem . 272 (6): 3663–8. doi :10.1074/jbc.272.6.3663 PMID 9013620 . Geppert M, Goda Y, Stevens CF, Südhof TC (1997). "The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle fusion" . Nature . 387 (6635): 810–4. doi :10.1038/42954 PMID 9194562 . S2CID 4359038 . Martincic I, Peralta ME, Ngsee JK (1997). "Isolation and characterization of a dual prenylated Rab and VAMP2 receptor" . J. Biol. Chem . 272 (43): 26991–8. doi :10.1074/jbc.272.43.26991 PMID 9341137 . Ostermeier C, Brunger AT (1999). "Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A" . Cell . 96 (3): 363–74. doi :10.1016/S0092-8674(00)80549-8 PMID 10025402 . S2CID 15162326 . Jung YJ, Lee TH, Lee JY, Kim JH, Park JB (1999). "Phosphatidic acid is important to the translocation of Rab3A from the cytosol to phospholipid membranes". NeuroReport . 10 (13): 2859–63. doi :10.1097/00001756-199909090-00029 . PMID 10511453 . Sullivan M, Olsen AS, Houslay MD (2000). "Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene and its chromosomal localisation to 19p13.1, between RAB3A and JUND". Cell. Signal . 11 (10): 735–42. doi :10.1016/S0898-6568(99)00037-6 . PMID 10574328 . Clabecq A, Henry JP, Darchen F (2000). "Biochemical characterization of Rab3-GTPase-activating protein reveals a mechanism similar to that of Ras-GAP" . J. Biol. Chem . 275 (41): 31786–91. doi :10.1074/jbc.M003705200 PMID 10859313 . Haynes LP, Evans GJ, Morgan A, Burgoyne RD (2001). "A direct inhibitory role for the Rab3-specific effector, Noc2, in Ca2+-regulated exocytosis in neuroendocrine cells" . J. Biol. Chem . 276 (13): 9726–32. doi :10.1074/jbc.M006959200 PMID 11134008 . Zhang Y, Luan Z, Liu A, Hu G (2001). "The scaffolding protein CASK mediates the interaction between rabphilin3a and beta-neurexins". FEBS Lett . 497 (2–3): 99–102. doi :10.1016/S0014-5793(01)02450-4 . PMID 11377421 . S2CID 33119468 . Luo HR, Saiardi A, Nagata E, Ye K, Yu H, Jung TS, Luo X, Jain S, Sawa A, Snyder SH (2001). "GRAB: a physiologic guanine nucleotide exchange factor for Rab3A, which interacts with inositol hexakisphosphate kinase" . Neuron . 31 (3): 439–51. doi :10.1016/S0896-6273(01)00384-1 PMID 11516400 . S2CID 10990373 . Piiper A, Leser J, Lutz MP, Beil M, Zeuzem S (2001). "Subcellular distribution and function of Rab3A-D in pancreatic acinar AR42J cells". Biochem. Biophys. Res. Commun . 287 (3): 746–51. doi :10.1006/bbrc.2001.5651 . PMID 11563859 . Kuroda TS, Fukuda M, Ariga H, Mikoshiba K (2002). "The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain" . J. Biol. Chem . 277 (11): 9212–8. doi :10.1074/jbc.M112414200 PMID 11773082 .
