Protein-coding gene in the species Homo sapiens
Ras-related protein Rab-21 is a protein that in humans is encoded by the RAB21 gene .[ 5] [ 6] [ 7] [ 8]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000080371 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020132 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Opdam FJ, Kamps G, Croes H, van Bokhoven H, Ginsel LA, Fransen JA (Oct 2000). "Expression of Rab small GTPases in epithelial Caco-2 cells: Rab21 is an apically located GTP-binding protein in polarised intestinal epithelial cells". Eur J Cell Biol . 79 (5): 308–16. doi :10.1078/S0171-9335(04)70034-5 . PMID 10887961 . ^ Pereira-Leal JB, Seabra MC (Nov 2001). "Evolution of the Rab family of small GTP-binding proteins". J Mol Biol . 313 (4): 889–901. doi :10.1006/jmbi.2001.5072 . PMID 11697911 . ^ Pellinen T, Arjonen A, Vuoriluoto K, Kallio K, Fransen JA, Ivaska J (Jun 2006). "Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins" . J Cell Biol . 173 (5): 767–80. doi :10.1083/jcb.200509019 . PMC 2063892 PMID 16754960 . ^ "Entrez Gene: RAB21 RAB21, member RAS oncogene family" .
Further reading
Nagase T, Miyajima N, Tanaka A, et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1" . DNA Res . 2 (1): 37–43. doi :10.1093/dnares/2.1.37 PMID 7788527 . Bao S, Zhu J, Garvey WT (1999). "Cloning of Rab GTPases expressed in human skeletal muscle: studies in insulin-resistant subjects". Horm. Metab. Res . 30 (11): 656–62. doi :10.1055/s-2007-978953 . PMID 9918381 . S2CID 23540699 . Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination" . Genome Res . 10 (11): 1788–95. doi :10.1101/gr.143000 . PMC 310948 PMID 11076863 . Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing" . EMBO Rep . 1 (3): 287–92. doi :10.1093/embo-reports/kvd058 . PMC 1083732 PMID 11256614 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline" . Genome Res . 14 (10B): 2136–44. doi :10.1101/gr.2576704 . PMC 528930 PMID 15489336 . Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006" . Nucleic Acids Res . 34 (Database issue): D415–8. doi :10.1093/nar/gkj139 . PMC 1347501 PMID 16381901 .
PDB gallery
1yzt : GppNHp-Bound Rab21 GTPase at 2.05 A Resolution
1yzu : GppNHp-Bound Rab21 GTPase at 2.50 A Resolution
1z08 : GppNHp-Bound Rab21 Q53G mutant GTPase
1z0i : GDP-Bound Rab21 GTPase
2ot3 : Crystal structure of rabex-5 VPS9 domain in complex with nucleotide free RAB21
