Prue Yai is a sub-district of Khukhan District, Sisaket Province. Its name means "Great Forest" because in the past, this area was the great forest before.

• 1907 Prue Yai was a sub-district of Huai Nuea District (Khukhan District), Khukhan Provine (Sisaket Province)
• 1986 Na Lawia Village and Sawai Pheng Village were divided from Prue Yai in order to establish Nikhom Phatthana Sub-district and Khok Tan Sub-district was divided from Prue Yai.
• 1988 Takhian Ram Sub-district was divided from Prue Yai
• 1990 Dong Rak Sub-district was divided from Khok Tan

The sub-district is divided into 20 villages (Muban), arranging by village number (Mu) as follows:

• Mu 1 Prue Yai
• Mu 2 Lak
• Mu 3 Ta Bo
• Mu 4 Makham
• Mu 5 Prue Khan Tawan-ok
• Mu 6 Non Sombun
• Mu 7 Prue Khan Tawantok
• Mu 8 Pho Sawang
• Mu 9 Khlong Lamchiak
• Mu 10 Ket Na Kho
• Mu 11 Noen Saeng
• Mu 12 Saen Suk
• Mu 13 Na Charia
• Mu 14 Prue Khan Tai
• Mu 15 Bang Krawan
• Mu 16 Nong Asen
• Mu 17 Thung Chai
• Mu 18 Noen Seri
• Mu 19 Nong Sim
• Mu 20 Na Kho

• Prue Yai Health Promoting Hospital
• Prue Khan Health Promoting Hospital
• Tabtim Siam 06 Health Promoting Hospital

• Primary
  • Prue Khan School
  • Makham School
  • Lak School
  • Non Sombun School
  • Tabtim Siam 06 School
• Primary and middle
  • Prue Yai School
• Middle and High
  • Prue Yai Witthayabanlang School

People are mostly Theravada Buddhists, there are seven temples in the sub-district

• Maha Nikaya
  • Prue Khan Temple (The temple of Khukhan district monk dean)
  • Prue Yai Temple (The temple of Phu Sing district monk dean)
  • Ta Bo Ket Mongkhon Temple
  • Pho Sawang Temple
  • Non Sombun Temple
• Dhammayuttika Nikaya
  • Sa Phong Cave Temple
  • Pa Mamuang Temple without royal bound Buddhist stone (leave)

• Tabtim Siam 06 Royal Project
• Chulabhorn Wildlife Breeding Center
• Sa Phong Cave Temple
• Morakot Cliff