Porzio is an Italian surname that may refer to:

• Alfredo Porzio (1900–1976), Argentinian boxer
• Camillo Porzio (1526–1580), Italian historian
• Francesco Porzio (born 1966), Italian water polo player
• Giovanni Porzio (1873–1962), Italian politician and lawyer
• Lorenzo Porzio (born 1981), Italian rower
• Mike Porzio (born 1972), American baseball player
• Nino Porzio (born 1972), Italian singer and actor
• Pino Porzio (born 1967), Italian water polo player
• Simone Porzio (1496–1554), Italian philosopher