Ponce may refer to:

• Ponce (surname)
• Ponce (streamer) (born 1991), French streamer
• Ponce, Puerto Rico, a city in Puerto Rico
  • Ponce High School
  • Ponce massacre, 1937
• USS Ponce, several ships of the US Navy
• Manuel Ponce, a Mexican composer active in the 20th century
• British and Irish slang for a pimp, also used figuratively to refer to an effeminate man
• Chaudin, cajun food, also referred to as ponce

• Ponce Inlet, Florida, a town in Florida, US
• Ponce de León (disambiguation)
• Ponce de Leon, Florida, a town in Florida, US
• Ponce de Leon, Missouri, an unincorporated community in Missouri, US
• Ponce de Leon Avenue, Atlanta, Georgia, US
• Ponce de Leon Bay, a bay in Florida, US
• Ponce de Leon Springs State Recreation Area, Holmes County, Florida, US