Pestilence may refer to:

• Infectious disease
• Pestilence, one of the Four Horsemen of the Apocalypse
• Pestilence (band), a Dutch death metal group
• Pestilence (comics), a Marvel Comics supervillain, based on the biblical horseman
• "Pestilence" (Medici: Masters of Florence), a television episode
• "The Pestilence", a song by Kreator from Pleasure to Kill
• "The Pestilence" is another name for the Black Death.

• Pestilence wort, a perennial plant native to Europe and northern Asia
• Category:Plague gods
• Pest (disambiguation)