Pest or The Pest may refer to:

• Pest (organism), an animal or plant deemed to be detrimental to humans or human concerns
  • Weed, a plant considered undesirable
• Infectious disease, an illness resulting from an infection
  • Plague (disease), an infectious disease caused by the bacterium Yersinia pestis
    • Black Death (the Plague), the deadliest pandemic recorded in human history

• The Pest (1914 film), an American short film starring Charlie Chaplin
• The Pest (1917 film), an American film starring Oliver Hardy
• The Pest (1919 film), an American film starring Mabel Normand
• The Pest (1922 film), an American film starring Stan Laurel
• The Pest (1997 film), an American film starring John Leguizamo

• Pest (band), a British music group
• Pest (musician) (born 1975), Norwegian black metal vocalist

• Pest, Hungary, the geographic region of Budapest
  • Royal University of Pest
• Pest County, an administrative division of Hungary, surrounding Budapest

• PESTS, an anonymous activist arts group
• Pest (ice hockey), an ice hockey player specialising in aggravating opponents

• PEST (disambiguation)
• Pestilence (disambiguation)
• Annoyance, a mental state characterized by irritation and distraction