Paint Creek may refer to:

• Paint Creek (Iowa), a tributary of the Upper Mississippi River
• Paint Creek (Kansas)
• Paint Creek (Johnson County, Kentucky), a tributary of the Levisa Fork
• Paint Creek (Oakland County, Michigan), a tributary of the Clinton River
• Paint Creek (Washtenaw County, Michigan), a tributary of Stony Creek
• Paint Creek (Montana), a stream in Flathead County
• Paint Creek (Scioto River), a tributary of the Scioto River in Ohio
• Paint Creek (Sevenmile Creek), a stream in Preble County, Ohio
• Paint Creek, Texas, an unincorporated community in Haskell County
• Paint Creek (West Virginia), a tributary of the Kanawha River
• Paint Creek Township, Allamakee County, Iowa